I am interested in studying hormone driven/sensitive cancers (prostate, endometrial and breast cancers). My work focuses on elucidating the mechanisms by which tumours evolve in time and space.

Currently I am contributing to the Pan-Prostate Cancer Group (PPCG) project where we are working on identifying genomic features that drive the progression of aggressive prostate cancer and the evolutionary routes that tumours follow from the early stages of cancer development to metastasis. Within PPCG, I am also involved in the Evolution and Heterogeneity Working Group where we are trying to characterise the heterogeneity of tumours collected at different stages of disease progression and after different courses of treatment. One other aspect of my research includes the investigation of Androgen Receptor (AR) driven genomic (Single Nucleotide Variations SNVs, simple and complex Structural Variations SVs and gene fusions) and epigenetic (methylation patterns and chromatin structure) alterations and the role they play in cancer biology. Some of my work is also dedicated to genomic variant calling and quality control. Relying on a massive amount of data from heterogeneous sources to conduct our analyses, it is important to develop the tools necessary to properly and efficiently curate and harmonise the data we are using.

An ambition of mine is to look beyond the genomics of cancer and develop Integrative approaches that use multi-level data (DNA, gene expression, epigenetics, pathology, medical imaging and clinical data) to gain more comprehensive and detailed insights into cancer and help translate our findings to the clinic for the purposes of providing patients with early detection tools, more accurate prognosis and tailored treatment strategies.