David C Wedge

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• Genomic Landscape of Diffuse Glioma Revealed by Whole Genome Sequencing
• Cancer Origin Tracing and Timing in Two High-Risk Prostate Cancers Using Multisample Whole Genome Analysis: Prospects for Personalized Medicine
• Cancer Driver Genes and Opportunities for Precision Oncology Revealed by Whole Genome Sequencing 10,478 Cancers
• Hypoxia Coordinates the Spatial Landscape of Myeloid Cells within Glioblastoma to Affect Outcome
• Comprehensive Repertoire of the Chromosomal Alteration and Mutational Signatures across 16 Cancer Types from 10,983 Cancer Patients.
• Abstract PR012: Ultra-Sensitive Detection of Circulating Tumour DNA Enriches for Patients with Higher Risk Disease in Clinically Localised Prostate Cancer
• Abstract 1166: APOBEC Deaminases Compete with Tobacco Smoking Mutagenesis and Affect Age at Onset of Lung Cancer
• Abstract 2088: gCNV-Seeker: A Comprehensive Germline CNV Calling Pipeline Based on Whole Genome Sequencing Data
• Abstract 6463: Persistence of Smoking Mutational Signatures in the Non-Small Cell Lung Cancer Genome
• Intra-Prostatic Tumour Evolution, Steps in Metastatic Spread and Histogenomic Associations Revealed by Integration of Multi-Region Whole Genome Sequencing with Histopathological Features
• Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy–Driven Metabolic Reprogramming
• The Genomic Landscape and Clonal Evolutionary Trajectory of Classical Hairy Cell Leukemia
• OGC P04 Spatial Sampling of Barrett's Oesophagus Reveals That Tumour Heterogeneity Is Not a Useful Predictor of Progression to Cancer
• Whole Genome Sequencing of 2,023 Colorectal Cancers Reveals Mutational Landscapes, New Driver Genes and Immune Interactions
• Genomic Panorama and Clonal Evolutionary Trajectory of Classical Hairy Cell Leukemia
• Uncovering Novel Mutational Signatures by de Novo Extraction with SigProfilerExtractor
• The Architecture of Clonal Expansions in Morphologically Normal Tissue from Cancerous and Non-Cancerous Prostates
• Clonal Diversification and Histogenesis of Malignant Germ Cell Tumours
• Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
• Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study
• Crowd-Sourced Benchmarking of Single-Sample Tumour Subclonal Reconstruction
• In Utero Origin of Myelofibrosis Presenting in Adult Monozygotic Twins
• APOBEC3 Mutational Signatures Are Associated with Extensive and Diverse Genomic Instability across Multiple Tumour Types
• Germline MBD4 Deficiency Causes a Multi-Tumor Predisposition Syndrome
• Multi-Omic Cross-Sectional Cohort Study of Pre-Malignant Barrett’s Esophagus Reveals Early Structural Variation and Retrotransposon Activity
• A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples
• Benchmarking Small-Variant Genotyping in Polyploids
• Changes in Clonal Architecture Inform MPN Disease Course in Advance of Phenotypic Manifestations
• P-OGC44 Multi-Omic Cohort Study of Barrett’s Oesophagus Reveals Structural Variation and Retrotransposon Activity to Occur Early in Cancer Evolution
• Whole-Genome Analysis of Nigerian Patients with Breast Cancer Reveals Ethnic-Driven Somatic Evolution and Distinct Genomic Subtypes
• P-061: Single-Cell Whole-Exome DNA Sequencing Traces Clonal Trajectory in Paired Evolution of MGUS to Multiple Myeloma
• Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity
• Genomic and Evolutionary Classification of Lung Cancer in Never Smokers
• Tumor Heterogeneity
• Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers: The Sherlock-Lung Study
• Accurate Genotyping of Single Cells with Octopus
• P0427 - Localised Activation of the EMT Switch by Peri-Neural Invading Epithelial Cells in Prostate Cancer
• A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease
• Germline Loss-of-Function Variants in the Base-Excision Repair Gene MBD4 Cause a Mendelian Recessive Syndrome of Adenomatous Colorectal Polyposis and Acute Myeloid Leukaemia
• Characterizing Genetic Intra-Tumor Heterogeneity across 2,658 Human Cancer Genomes
• A Unified Haplotype-Based Method for Accurate and Comprehensive Variant Calling
• Promises and Challenges of Adoptive T-Cell Therapies for Solid Tumours
• Re-Evaluating Experimental Validation in the Big Data Era: A Conceptual Argument
• Abstract: Localized Activation of the Metastatic Phenotype within the Perineural Region in Prostate Cancer.
• A Practical Guide to Cancer Subclonal Reconstruction from DNA Sequencing
• Evolution and Lineage Dynamics of a Transmissible Cancer in Tasmanian Devils
• Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study
• Prostate Cancer Evolution from Multilineage Primary to Single Lineage Metastases with Implications for Liquid Biopsy
• Multi-Site Clonality Analysis Uncovers Pervasive Heterogeneity across Melanoma Metastases
• Genomic Copy Number Predicts Esophageal Cancer Years before Transformation
• Malignant Transformation and Genetic Alterations Are Uncoupled in Early Colorectal Cancer Progression
• Harnessing the Power of RNA in Determining the Origin of Lethal Micro-Metastatic Prostate Cancer
• The Genomic and Epigenomic Evolutionary History of Papillary Renal Cell Carcinomas
• Reference Bias in the Illumina Isaac Aligner
• Genetic and Epigenetic Intratumor Heterogeneity Impacts Prognosis of Lung Adenocarcinoma
• Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2: ERG Fusion Status and Immune Cell Infiltration
• DNA Copy Number Motifs Are Strong and Independent Predictors of Survival in Breast Cancer
• The Evolutionary History of 2,658 Cancers
• A Community Effort to Create Standards for Evaluating Tumor Subclonal Reconstruction
• Genomic Evidence Supports a Clonal Diaspora Model for Metastases of Esophageal Adenocarcinoma
• Embryonal Precursors of Wilms Tumor
• Correcting Reference Bias from the Illumina Isaac Aligner Enables Analysis of Cancer Genomes
• P1. 08-A Sherlock Lung Tracing Lung Cancer Mutational Processes in Never-Smokers
• GCT-21 - Testicular Cancer Genomics England Clinical Interpretation Partnership (GECIP): A Genomic Exploration of Testicular Germ Cell Tumours
• Genomic Landscape and Chronological Reconstruction of Driver Events in Multiple Myeloma
• Profiling Molecular Regulators of Recurrence in Chemorefractory Triple-Negative Breast Cancers
• Abstract LB-300: The Life History of Breast Cancer in Nigerian Women: Evidence for Ethnic Differences in Tumor Evolution Based on Whole-Genome Sequencing
• Abstract SY26-02: Sherlock-Lung: Tracing Lung Cancer Mutational Processes in Never Smokers
• Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis
• The Preliminary Results from the 100,000 Genomes Project: The Genomic Landscape of Colorectal Cancer
• Time Series Analysis of Neoadjuvant Chemotherapy and Bevacizumab-Treated Breast Carcinomas Reveals a Systemic Shift in Genomic Aberrations
• Neutral Tumor Evolution?
• The Genomic Landscape of Structural Variations and Complex Events in Multiple Myeloma
• Classification and Personalized Prognosis in Myeloproliferative Neoplasms
• Analysis of Mutations and Structural Variants to Redefine the Genomic Landscape of Multiple Myeloma and Its Clinical Implications
• The Evolutionary Landscape of Colorectal Tumorigenesis
• Genomic Patterns of Progression in Smoldering Multiple Myeloma
• Organoid Cultures Recapitulate Esophageal Adenocarcinoma Heterogeneity Providing a Model for Clonality Studies and Precision Therapeutics
• Abstract 3000: Pervasive Intra-Tumour Heterogeneity and Subclonal Selection across Cancer Types
• 33 PAN-Cancer Whole Genome Sequencing Reveals Patterns of Subclonal Mutations, Signature Changes and Selection
• PO-322 Multi-Region Deep Sequencing of Colorectal Carcinoma in-Situ Defines Oncogenic Transformation as a Gradual and Adaptive Process
• PO-329 Rejecting Neutral Tumour Evolution across Human Cancer Types
• Sequencing of Prostate Cancers Identifies New Cancer Genes, Routes of Progression and Drug Targets
• Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
• Abstract P2-07-04: Molecular Regulators of Resistance and Relapse in Chemorefractory Triple-Negative Breast Cancers
• Pan-Cancer Analysis of Whole Genomes Reveals Driver Rearrangements Promoted by LINE-1 Retrotransposition in Human Tumours
• 635 - Personalized Prognostic Predictions for Patients with Myeloproliferative Neoplasms through Integration of Comprehensive Genomic and Clinical Information
• The Genomic Landscape of Multiple Myeloma Complex Structural Variations
• Pan-Cancer Analysis of Homozygous Deletions in Primary Tumours Uncovers Rare Tumour Suppressors
• Appraising the Relevance of DNA Copy Number Loss and Gain in Prostate Cancer Using Whole Genome DNA Sequence Data
• Genomic Evolution of Breast Cancer Metastasis and Relapse
• Principles of Reconstructing the Subclonal Architecture of Cancers
• Recurrent Mutation of IGF Signalling Genes and Distinct Patterns of Genomic Rearrangement in Osteosarcoma
• Somatic Mutations Reveal Asymmetric Cellular Dynamics in the Early Human Embryo
• How Subclonal Modeling Is Changing the Metastatic Paradigm
• 445 - Shallow Whole Genome Sequencing Can Detect Copy Number Changes in FFPE Material in the Progression of Barrett's Esophagus
• Tracing the Origin of Disseminated Tumor Cells in Breast Cancer Using Single-Cell Sequencing
• ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data
• 651 - Whole Genome Sequencing of Unique Paired Smm-Mgus Progressing to Mm Samples Reveals a Genomic Landscape with Diverse Evolutionary Pattern
• Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma
• The Complex Landscape of Rearrangements in Smoldering and Symptomatic Multiple Myeloma Revealed By Whole-Genome Sequencing
• Perturbed Hematopoietic Stem and Progenitor Cell Hierarchy in Myelodysplastic Syndromes Patients with Monosomy 7 as the Sole Cytogenetic Abnormality
• Mutational Signatures of Ionizing Radiation in Second Malignancies
• The Genomic Landscape of Pancreatic and Periampullary AdenocarcinomaCopy Number Aberrations in Periampullary Adenocarcinomas
• Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
• Abstract LB-337: Systemic Shift in Genomic Aberrations in Breast Carcinomas during Neoadjuvant Chemotherapy in Combination with Bevacizumab
• 361 - Genomic Evolution and Heterogeneity in 2,800 Cancers
• Mitochondrial Genetic Diversity, Selection and Recombination in a Canine Transmissible Cancer
• Landscape of Somatic Mutations in 560 Breast Cancer Whole-Genome Sequences
• Rapid Parallel Acquisition of Somatic Mutations after NPM1 in Acute Myeloid Leukaemia Evolution
• Abstract B09: DNA Polymerase Mutations Trigger Rapid Onset of Ultra-Hypermutant Malignant Brain Tumors in Children with Biallelic Mismatch Repair Deficiency
• Clock-like Mutational Processes in Human Somatic Cells
• 1818 - Evolution from Primary Breast Cancer to Relapse and Metastasis.
• DNMT3A Mutations Occur Early or Late in Patients with Myeloproliferative Neoplasms and Mutation Order Influences Phenotype
• Abstract LB-051: Tumor Heterogeneity and Dissemination in Breast Cancer: Deep Sequencing of Single Disseminated Cells from Bone Marrow Compared to Primary Tumor and Lymph Node Metastases
• Clonal Evolution of a Lethal Prostate Cancer: Integrated Whole Genome Analysis Case Study
• PTU-128 Novel Insights into Metastatic Spread of Oesophageal Adenocarcinoma from Whole Genome Sequencing Data
• Subclonal Diversification of Primary Breast Cancer Revealed by Multiregion Sequencing
• High Burden and Pervasive Positive Selection of Somatic Mutations in Normal Human Skin
• Concomitant Inactivation of the P53-and pRB-Functional Pathways Predicts Resistance to DNA Damaging Drugs in Breast Cancer in Vivo
• 168 Evolution of Copy Number Aberrations with Time and Gleason Grade in Localised Prostate Cancer
• The Evolutionary History of Lethal Metastatic Prostate Cancer
• Tracking the Origins and Drivers of Subclonal Metastatic Expansion in Prostate Cancer
• Analysis of the Genetic Phylogeny of Multifocal Prostate Cancer Identifies Multiple Independent Clonal Expansions in Neoplastic and Morphologically Normal Prostate Tissue
• Tracking Clonal Diversity in Metastatic Prostate Cancer Progression.
• Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study
• Effect of Mutation Order on Myeloproliferative Neoplasms
• Combined Hereditary and Somatic Mutations of Replication Error Repair Genes Result in Rapid Onset of Ultra-Hypermutated Cancers
• Diagnostic Value of H3F3A Mutations in Giant Cell Tumour of Bone Compared to Osteoclast-Rich Mimics
• Differential and Limited Expression of Mutant Alleles in Multiple Myeloma
• Intratumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multiregion Sequencing
• Spatial and Temporal Diversity in Genomic Instability Processes Defines Lung Cancer Evolution
• A Comparison of Different Chemometrics Approaches for the Robust Classification of Electronic Nose Data
• Intratumor Heterogeneity in Non-Small Cell Lung Cancer Inferred by Multi-Region Exome Sequencing
• Fast Randomization of Large Genomic Datasets While Preserving Alteration Counts
• Evolution of the Genomic Landscape in Non-Small Cell Lung Cancer
• Extensive Transduction of Nonrepetitive DNA Mediated by L1 Retrotransposition in Cancer Genomes
• Genome Sequencing of Normal Cells Reveals Developmental Lineages and Mutational Processes
• Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells in Vivo
• Genomic Heterogeneity in Primary Breast Cancer: Clinical Implications.
• Population Distribution and Ancestry of the Cancer Protective MDM2 SNP285 (Rs117039649)
• Association of a Germline Copy Number Polymorphism of APOBEC3A and APOBEC3B with Burden of Putative APOBEC-Dependent Mutations in Breast Cancer
• MP49-01 SUBCLONAL ORIGIN OF PROSTATE CANCER METASTASIS WITH MUTATOR PHENOTYPE FROM A NOVEL MSH2 GENE FUSION
• MP49-06 GENOMIC ANALYSIS OF MULTIPLE PROSTATE CANCER METASTASES HIGHLIGHTS METASTASIS FROM LOW-GRADE CANCER FOCI AND DYNAMIC ADAPTATIONS TO THERAPY
• Recurrent PTPRB and PLCG1 Mutations in Angiosarcoma
• Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage
• Heterogeneity of Genomic Evolution and Mutational Profiles in Multiple Myeloma
• RAG-Mediated Recombination Is the Predominant Driver of Oncogenic Rearrangement in ETV6-RUNX1 Acute Lymphoblastic Leukemia
• Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
• The Genetic Heterogeneity and Mutational Burden of Engineered Melanomas in Zebrafish Models
• Clinical and Biological Implications of Driver Mutations in Myelodysplastic Syndromes
• The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients
• Distinct H3F3A and H3F3B Driver Mutations Define Chondroblastoma and Giant Cell Tumor of Bone
• The Landscape of Tumor Suppressors across Human Cancers
• Signatures of Mutational Processes in Human Cancer
• Whole Exome Sequencing of Adenoid Cystic Carcinoma
• Frequent Mutation of the Major Cartilage Collagen Gene COL2A1 in Chondrosarcoma
• Kataegis and Other Somatic Mutational Signatures in Cancer
• ETV6-RUNX1 ALL, INSIGHTS FROM INTEGRATIVE GENOMIC ANALYSIS
• AID-APOBEC Cytidine Deaminases Can Mimic the Phenomenon of Localized Hypermutation in Cancer or Kataegis.
• A Comparison of Raman and FT-IR Spectroscopy for the Prediction of Meat Spoilage
• Deciphering Signatures of Mutational Processes Operative in Human Cancer
• Liquid Chromatography–Mass Spectrometry Calibration Transfer and Metabolomics Data Fusion
• 604 Cancer Genomics, Epigenetics and Genomic Instability. Mutational Processes Shaping the Genomes of Twenty-One Breast Cancers
• Mutational Processes Molding the Genomes of 21 Breast Cancers
• The Life History of 21 Breast Cancers
• The Landscape of Cancer Genes and Mutational Processes in Breast Cancer
• Exploring the Subclonal Architecture of Breast Cancer
• Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer
• CONSeQuence: Prediction of Reference Peptides for Absolute Quantitative Proteomics Using Consensus Machine Learning Approaches
• Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer
• Automated Workflows for Accurate Mass-Based Putative Metabolite Identification in LC-MS-Derived Metabolomic Datasets
• FDRAnalysis: A Tool for the Integrated Analysis of Tandem Mass Spectrometry Identification Results from Multiple Search Engines
• Predictive Models for Population Performance on Real Biological Fitness Landscapes
• Convergent Evolution to an Aptamer Observed in Small Populations on DNA Microarrays
• Analysis of a Complete DNA–Protein Affinity Landscape
• Fabrication of Planar Organic Nanotransistors Using Low Temperature Thermal Nanoimprint Lithography for Chemical Sensor Applications
• Real-Time Vapour Sensing Using an OFET-Based Electronic Nose and Genetic Programming
• P K a Prediction from “Quantum Chemical Topology” Descriptors
• Aptamer Evolution for Array-Based Diagnostics
• In Silico Modelling of Directed Evolution: Implications for Experimental Design and Stepwise Evolution
• Array-Based Evolution of DNA Aptamers Allows Modelling of an Explicit Sequence-Fitness Landscape
• Rapid Prediction of Optimum Population Size in Genetic Programming Using a Novel Genotype- Fitness Correlation
• Peptide Detectability Following ESI Mass Spectrometry: Prediction Using Genetic Programming
• On Global-Local Artificial Neural Networks for Function Approximation
• Wave Overtopping Prediction Using Global-Local Artificial Neural Networks
• Neural Network Architectures and Overtopping Predictions
• A Global-Local Artificial Neural Network with Application to Wave Overtopping Prediction
• African-Specific Molecular Taxonomy of Prostate Cancer
• Tandem Duplication of Chromosomal Segments Is Common in Ovarian and Breast Cancer Genomes