Ludmil B Alexandrov

Latest

• Comprehensive Repertoire of the Chromosomal Alteration and Mutational Signatures across 16 Cancer Types from 10,983 Cancer Patients.
• Abstract 1166: APOBEC Deaminases Compete with Tobacco Smoking Mutagenesis and Affect Age at Onset of Lung Cancer
• Whole Genome Sequencing of 2,023 Colorectal Cancers Reveals Mutational Landscapes, New Driver Genes and Immune Interactions
• Uncovering Novel Mutational Signatures by de Novo Extraction with SigProfilerExtractor
• Genomic and Evolutionary Classification of Lung Cancer in Never Smokers
• Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers: The Sherlock-Lung Study
• Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study
• The Genomic and Epigenomic Evolutionary History of Papillary Renal Cell Carcinomas
• Genomic Evidence Supports a Clonal Diaspora Model for Metastases of Esophageal Adenocarcinoma
• P1. 08-A Sherlock Lung Tracing Lung Cancer Mutational Processes in Never-Smokers
• Abstract SY26-02: Sherlock-Lung: Tracing Lung Cancer Mutational Processes in Never Smokers
• Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis
• Genomic Patterns of Progression in Smoldering Multiple Myeloma
• Sequencing of Prostate Cancers Identifies New Cancer Genes, Routes of Progression and Drug Targets
• Genomic Evolution of Breast Cancer Metastasis and Relapse
• Recurrent Mutation of IGF Signalling Genes and Distinct Patterns of Genomic Rearrangement in Osteosarcoma
• Somatic Mutations Reveal Asymmetric Cellular Dynamics in the Early Human Embryo
• Mutational Signatures of Ionizing Radiation in Second Malignancies
• Landscape of Somatic Mutations in 560 Breast Cancer Whole-Genome Sequences
• Abstract B09: DNA Polymerase Mutations Trigger Rapid Onset of Ultra-Hypermutant Malignant Brain Tumors in Children with Biallelic Mismatch Repair Deficiency
• Clock-like Mutational Processes in Human Somatic Cells
• Subclonal Diversification of Primary Breast Cancer Revealed by Multiregion Sequencing
• High Burden and Pervasive Positive Selection of Somatic Mutations in Normal Human Skin
• The Evolutionary History of Lethal Metastatic Prostate Cancer
• Tracking the Origins and Drivers of Subclonal Metastatic Expansion in Prostate Cancer
• Analysis of the Genetic Phylogeny of Multifocal Prostate Cancer Identifies Multiple Independent Clonal Expansions in Neoplastic and Morphologically Normal Prostate Tissue
• Tracking Clonal Diversity in Metastatic Prostate Cancer Progression.
• Combined Hereditary and Somatic Mutations of Replication Error Repair Genes Result in Rapid Onset of Ultra-Hypermutated Cancers
• Fast Randomization of Large Genomic Datasets While Preserving Alteration Counts
• Extensive Transduction of Nonrepetitive DNA Mediated by L1 Retrotransposition in Cancer Genomes
• Genome Sequencing of Normal Cells Reveals Developmental Lineages and Mutational Processes
• Association of a Germline Copy Number Polymorphism of APOBEC3A and APOBEC3B with Burden of Putative APOBEC-Dependent Mutations in Breast Cancer
• MP49-06 GENOMIC ANALYSIS OF MULTIPLE PROSTATE CANCER METASTASES HIGHLIGHTS METASTASIS FROM LOW-GRADE CANCER FOCI AND DYNAMIC ADAPTATIONS TO THERAPY
• Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage
• Heterogeneity of Genomic Evolution and Mutational Profiles in Multiple Myeloma
• RAG-Mediated Recombination Is the Predominant Driver of Oncogenic Rearrangement in ETV6-RUNX1 Acute Lymphoblastic Leukemia
• Signatures of Mutational Processes in Human Cancer
• ETV6-RUNX1 ALL, INSIGHTS FROM INTEGRATIVE GENOMIC ANALYSIS
• Deciphering Signatures of Mutational Processes Operative in Human Cancer
• 604 Cancer Genomics, Epigenetics and Genomic Instability. Mutational Processes Shaping the Genomes of Twenty-One Breast Cancers
• Mutational Processes Molding the Genomes of 21 Breast Cancers
• The Life History of 21 Breast Cancers
• Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer