I am investigating Hereditary Diffuse Gastric Cancer (HDGC) in Prof. David Wedge’s world-renowned cancer computational group. This is my first job since retraining as a bioinformatician having just completed an MSc in Bioinformatics and Systems biology at the University of Manchester. Previously, I spent many years as a life-sciences post-doc researching conserved signalling pathways in the fruit-fly, which has given me a broad understanding of biology. I was motivated to switch fields to bioinformatics by this exciting era where aetiology of human diseases may be further elucidated by mining big data. The project I am involved in is a short pilot study to try and ascertain what extra mutational changes may be driving people with familial stomach cancer, often associated with germline loss-of-function mutations in one copy of the E-cadherin gene, to develop cancerous metastatic lesions. HDGC represents about 3% of all stomach cancers. It frequently develops before the age of forty and if diagnosed only once it has become widely invasive, has a survival rate of merely 20%.