Publications

Ben Kinnersley, Josephine Jung, Alex Cornish, Daniel Chubb, Ross Laxton, Anna Frangou, Andreas J Gruber, Amit Sud, Giulio Caravagna, Andrea Sottoriva, David C Wedge, Thomas Booth, Safa Al-Sarraj, Sam Lawrence, Erminia Albanese, Guilio Anichini, David Baxter, Alexandros Boukas, Yasir Chowdhury, Pietro D'Urso, Robert Corns, Andrew Dapaah, Ellie Edlmann, Fay Greenway, Paul Grundy, Ciaran Hill, Michael Jenkinson, Sandhya Krishna, Stuart Smith, Susruta Manivannan, Andrew Martin, Samir Matloob, Soumya Mukherjee, Kevin O'Neill, Puneet Plaha, Jonathan Pollock, Stephen Price, Ola Rominiyi, Bobby Sachdev, Fozia Saeed, Saurabh Sinha, Lewis Thorne, Ismail Ughratdar, Peter Whitfield, Amir Youshani, Helen Bulbeck, Prabhu Arumugam, Richard S Houlston, Ashkan Keyoumars (2023). Genomic Landscape of Diffuse Glioma Revealed by Whole Genome Sequencing. ResearchSquare https://doi.org/10.21203/rs.3.rs-3470361/v1.

Anssi Nurminen, Serafiina Jaatinen, Sinja Taavitsainen, Gunilla Hognas, Tom Lesluyes, Naser Ansari-Pour, Teemu Tolonen, Kerstin Haase, Antti Koskenalho, Matti Kankainen, Juho Jasu, Hanna Rauhala, Jenni Kesaniemi, Tiia Nikupaavola, Paula Kujala, Irina Rinta-Kiikka, Jarno Riikonen, Antti Kaipia, Teemu Murtola, Teuvo L Tammela, Tapio Visakorpi, Matti Nykter, David C Wedge, Peter Van Loo, G Steven Bova (2023). Cancer Origin Tracing and Timing in Two High-Risk Prostate Cancers Using Multisample Whole Genome Analysis: Prospects for Personalized Medicine. Genome Medicine, 15(1) 82. Springer https://doi.org/10.1186/s13073-023-01242-y.

Ben Kinnersley, Amit Sud, Andrew Everall, Alex J Cornish, Daniel Chubb, Richard Culliford, Andreas J Gruber, Adrian Larkeryd, Costas Mitsopoulos, Genomics England Research Consortium, David C Wedge, Richard S Houlston (2023). Cancer Driver Genes and Opportunities for Precision Oncology Revealed by Whole Genome Sequencing 10,478 Cancers. medRxiv 2023.05. 24.23289454. Cold Spring Harbor Laboratory Press https://doi.org/10.1101/2023.05.24.23289454.

Michael J Haley, Leoma Bere, James Minshull, Sokratia Georgaka, Natalia Garcia Martin, Gareth Howell, David J Coope, Federico Roncaroli, Andrew King, David C Wedge, Stuart Allan, Omar N Pathmanaban, David Brough, Kevin Couper (2023). Hypoxia Coordinates the Spatial Landscape of Myeloid Cells within Glioblastoma to Affect Outcome. bioRxiv 2023.06. 30.547190. Cold Spring Harbor Laboratory https://doi.org/10.1101/2023.06.30.547190.

Andrew Everall, Avraam Tapinos, Aliah Hawari, Alex Cornish, Amit Sud, Daniel Chubb, Ben Kinnersley, Anna Frangou, Miguel Barquin, Josephine Jung, David Church, Genomics England Research Consortium, Ludmil B Alexandrov, Richard S Houlston, Andreas J Gruber, David C Wedge (2023). Comprehensive Repertoire of the Chromosomal Alteration and Mutational Signatures across 16 Cancer Types from 10,983 Cancer Patients.. medRxiv 2023.06. 07.23290970. Cold Spring Harbor Laboratory Press https://doi.org/10.1101/2023.06.07.23290970.

Bernard J Pope, Gahee Park, Edmund Lau, Jelena Belic, Radoslaw Lach, Anne George, Patrick McCoy, Anne Nguyen, Corrina Grima, Chol-hee Jung, Emma-Jane Ditter, Hui Zhao, David C Wedge, Rosalind A Eeles, Daniel S Brewer, Andrew G Lynch, Harveer Dev, Christopher M Hovens, Vincent Gnanapragasam, Nitzan Rosenfeld, Niall M Corcoran, Charles E Massie (2023). Abstract PR012: Ultra-Sensitive Detection of Circulating Tumour DNA Enriches for Patients with Higher Risk Disease in Clinically Localised Prostate Cancer. Cancer Research, 83(11 Supplement) PR012-PR012. AACR https://doi.org/10.1158/1538-7445.PRCA2023-PR012.

Colin R Lindsay, Pantelis Nicola, Andreas Gruber, Kate Brown, Mathew Carter, Helen Adderley, Shereen Rafee, Anna Moss, Andrew Wallace, George Burghel, Helene Schlecht, Katie Baker, Sharzad Moghadam, Jane Rogan, Jamie Weaver, Angeliki Malliri, William Newman, Fiona H Blackhall, David C Wedge, Genomics England (2023). Abstract 6463: Persistence of Smoking Mutational Signatures in the Non-Small Cell Lung Cancer Genome. Cancer Research, 83(7 Supplement) 6463–6463. AACR https://doi.org/10.1158/1538-7445.AM2023-6463.

Jian Sang, Tongwu Zhang, David C Wedge, Maria Teresa Landi (2023). Abstract 2088: gCNV-Seeker: A Comprehensive Germline CNV Calling Pipeline Based on Whole Genome Sequencing Data. Cancer Research, 83(7 Supplement) 2088–2088. AACR https://doi.org/10.1158/1538-7445.AM2023-2088.

Tongwu Zhang, Jian Sang, Phuc H Hoang, Wei Zhao, Jennifer Rosenbaum, Leszek J Klimczak, John McElderry, Alyssa Klein, Christopher Wirth, Erik N Bergstrom, Marcos Diaz-Gay, Raviteja Vangara, Amy Hutchinson, Scott M Lawrence, Nathan Cole, Bin Zhu, Teresa M Przytycka, Jianxin Shi, Neil E Caporaso, Robert Homer, Angela C Pesatori, Dario Consonni, Stephen J Chanock, David C Wedge, Dmitry A Gordenin, Ludmil B Alexandrov, Reuben S Harris, Maria Teresa Landi (2023). Abstract 1166: APOBEC Deaminases Compete with Tobacco Smoking Mutagenesis and Affect Age at Onset of Lung Cancer. Cancer Research, 83(7 Supplement) 1166–1166. AACR https://doi.org/10.1158/1538-7445.AM2023-1166.

Srinivasa Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O'Hanlon, Alicia Hayes, Adam Lambert, Martha James, Iain DC Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco Lopez, Tom Leslie, Francesca Buffa, Richard J Bryant, Alastair D Lamb, Boris Vojnovic, David C Wedge, Ian G Mills, Dan J Woodcock, Ian P M Tomlinson, Freddie C Hamdy (2023). Intra-Prostatic Tumour Evolution, Steps in Metastatic Spread and Histogenomic Associations Revealed by Integration of Multi-Region Whole Genome Sequencing with Histopathological Features. bioRxiv 2023.02. 27.530113. Cold Spring Harbor Laboratory https://doi.org/10.1101/2023.02.27.530113.

Marni B McClure, Yasunori Kogure, Naser Ansari-Pour, Yuki Saito, Hann-Hsiang Chao, Jonathan Shepherd, Mariko Tabata, Olufunmilayo I Olopade, David C Wedge, Katherine A Hoadley, Charles M Perou, Keisuke Kataoka (2023). Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy–Driven Metabolic Reprogramming. Cancer Research Communications, 3(2) 281–296. AACR https://doi.org/10.1158/2767-9764.CRC-22-0073.

Luz Yurany Moreno Rueda, Dean Bryant, William J Tapper, Nicola J Weston-Bell, David C Wedge, Naser Ansari-Pour, Surinder S Sahota (2023). The Genomic Landscape and Clonal Evolutionary Trajectory of Classical Hairy Cell Leukemia. Leukemia, 37(4) 929–933. Nature Publishing Group UK London https://doi.org/10.1038/s41375-023-01823-1.

Annalise Katz-Summercorn, Iliana Peneva, Anna Frangou, Sriganesh Jammula, Maria O'Donovan, Monika Tripathi, Shalini Malhotra, Massimiliano di Pietro, Ginny Devonshire, Aisling Redmond, David C Wedge, Rebecca C Fitzgerald (2022). OGC P04 Spatial Sampling of Barrett's Oesophagus Reveals That Tumour Heterogeneity Is Not a Useful Predictor of Progression to Cancer. British Journal of Surgery, 109(Supplement 9) znac404. 167. Oxford University Press US https://doi.org/10.1093/bjs/znac404.167.

Alex J Cornish, Andreas J Gruber, Ben Kinnersley, Daniel Chubb, Anna Frangou, Giulio Caravagna, Boris Noyvert, Eszter Lakatos, Henry Wood, Claudia Arnedo-Pac, Richard Culliford, Jacob Househam, William Cross, Amit Sud, Philip Law, Maire Ni Leathlobhair, Aliah Hawari, Steve Thorn, Kitty Sherwood, Guler Gul, Juan Fernandez-Tajes, Luis Zapata, Ludmil B Alexandrov, Nirupa Murugaesu, Alona Sosinsky, Jonathan Mitchell, Genomics England Research Consortium, Nuria Lopez-Bigas, Philip Quirke, David Church, Ian P M Tomlinson, Andrea Sottoriva, Trevor A Graham, David C Wedge, Richard S Houlston (2022). Whole Genome Sequencing of 2,023 Colorectal Cancers Reveals Mutational Landscapes, New Driver Genes and Immune Interactions. bioRxiv 2022.11. 16.515599. Cold Spring Harbor Laboratory https://doi.org/10.1101/2022.11.16.515599.

Luz Yurany Moreno Rueda, Dean Bryant, William J Tapper, Nicky Weston-Bell, David C Wedge, Naser Ansari-Pour, Surinder S Sahota (2022). Genomic Panorama and Clonal Evolutionary Trajectory of Classical Hairy Cell Leukemia. Blood, 140(Supplement 1) 8748–8749. American Society of Hematology https://doi.org/10.1182/blood-2022-159812.

SM Ashiqul Islam, Marcos Diaz-Gay, Yang Wu, Mark Barnes, Raviteja Vangara, Erik N Bergstrom, Yudou He, Mike Vella, Jingwei Wang, Jon W Teague, Peter Clapham, Sarah Moody, Sergey Senkin, Yun Rose Li, Laura Riva, Tongwu Zhang, Andreas J Gruber, Christopher D Steele, Burcak Otlu, Azhar Khandekar, Ammal Abbasi, Laura Humphreys, Natalia Syulyukina, Samuel W Brady, Boian S Alexandrov, Nischalan Pillay, Jinghui Zhang, David J Adams, Inigo Martincorena, David C Wedge, Maria Teresa Landi, Paul Brennan, Michael R Stratton, Steven G Rozen, Ludmil B Alexandrov (2022). Uncovering Novel Mutational Signatures by de Novo Extraction with SigProfilerExtractor. Cell Genomics Cold Spring Harbor Laboratory https://doi.org/10.1016/j.xgen.2022.100179.

Claudia Buhigas, Anne Y. Warren, Wing-Kit Leung, Hayley C. Whitaker, Hayley J. Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J Woodcock, Sue Merson, Fiona M Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Inigo Martincorena, G Steven Bova, Christopher S Foster, Peter J Campbell, Norman J Maitland, David E Neal, Charles E Massie, Andrew G Lynch, Rosalind A Eeles, Colin S Cooper, David C Wedge, Daniel S Brewer (2022). The Architecture of Clonal Expansions in Morphologically Normal Tissue from Cancerous and Non-Cancerous Prostates. Molecular cancer, 21(1) 183. Springer https://doi.org/10.1186/s12943-022-01644-3.

Thomas RW Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C Dentro, Matthew D Young, Tim HH Coorens, Hyunchul Jung, Tim Butler, Matthew D C Neville, Daniel Leongamornlert, Mathijs A Sanders, Yvette Hooks, Alex Cagan, Thomas J Mitchell, Isidro Cortes-Ciriano, Anne Y Warren, David C Wedge, Rakesh Heer, Nicholas Coleman, Matthew J Murray, Peter J Campbell, Raheleh Rahbari, Sam Behjati (2022). Clonal Diversification and Histogenesis of Malignant Germ Cell Tumours. Nature communications, 13(1) 1–12. Nature Publishing Group https://doi.org/10.1038/s41467-022-31375-4.

Rachel Hurst, Emma Meader, Abraham Gihawi, Ghanasyam Rallapalli, Jeremy Clark, Gemma L Kay, Martyn Webb, Kate Manley, Helen Curley, Helen Walker, Ravi Kumar, Katarzyna Schmidt, Lisa Crossman, Rosalind A Eeles, David C Wedge, Andrew G Lynch, Charles E Massie, CRUK-ICGC Prostate Group, Marcelino Yazbek-Hanna, Mark Rochester, Robert D Mills, Richard F Mithen, Maria H Traka, Richard Y Ball, Justin O'Grady, Daniel S Brewer, John Wain, Colin S Cooper (2022). Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups. European Urology Oncology, 5(4) 412–419. Elsevier https://doi.org/10.1016/j.euo.2022.03.006.

Daniel Burns, Ezequiel Anokian, Edward J Saunders, Robert G Bristow, Michael Fraser, Juri Reimand, Thorsten Schlomm, Guido Sauter, Benedikt Brors, Jan Korbel, Joachim Weischenfeldt, Sebastian M Waszak, Niall M Corcoran, Cheol-Hee Jung, Bernard J Pope, Christopher M Hovens, Geraldine Cancel-Tassin, Olivier Cussenot, Massimo Loda, Chris Sander, Vanessa M Hayes, Karina Dalsgaard Sorensen, Yong-Jie Lu, Freddie C Hamdy, Christopher S Foster, Vincent Gnanapragasam, Adam Butler, Andrew G Lynch, Charles E Massie, CRUK/Prostate Cancer UK, ICGC, The PPCG, Dan J Woodcock, Colin S Cooper, David C Wedge, Daniel S Brewer, Zsofia Kote-Jarai, Rosalind A Eeles (2022). Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study. European Urology, 82(2) 201–211. Elsevier https://doi.org/10.1016/j.eururo.2022.05.007.

Adriana Salcedo, Maxime Tarabichi, Alex Buchanan, Shadrielle MG Espiritu, Hongjui Zhang, Kaiyi Zhu, Tai-Hsien Ou Yang, Ignaty Leshchiner, Dimitris Anastassiou, Yuanfang Guan, Gun Ho Jang, Kerstin Haase, Amit G Deshwar, William Zou, Imad Umar, Stefan Dentro, Jeff A Wintersinger, Kami Chiotti, Jonas Demeulemeester, Clemency Jolly, Lesia Sycza, Minjeong Ko, PCAWG-11 Working Group, SMC-Het Participants, David C Wedge, Quaid D Morris, Kyle Ellrott, Peter Van Loo, Paul C Boutros (2022). Crowd-Sourced Benchmarking of Single-Sample Tumour Subclonal Reconstruction. bioRxiv Cold Spring Harbor Laboratory https://doi.org/10.1101/2022.06.14.495937.

Nikolaos Sousos, Maire Ni Leathlobhair, Christina Simoglou Karali, Eleni Louka, Nicola Bienz, Daniel Royston, Sally-Ann Clark, Angela Hamblin, Kieran Howard, Vikram Mathews, George, Biju, Anindita Roy, Bethan Psaila, David C Wedge, Adam J Mead (2022). In Utero Origin of Myelofibrosis Presenting in Adult Monozygotic Twins. Nature Medicine, 28 1207–1211. Nature Publishing Group https://doi.org/10.1038/s41591-022-01793-4.

G. Maria Jakobsdottir, Daniel S Brewer, Colin Cooper, Catherine Green, David C Wedge (2022). APOBEC3 Mutational Signatures Are Associated with Extensive and Diverse Genomic Instability across Multiple Tumour Types. BMC biology, 20(1) 1–12. BioMed Central https://doi.org/10.1186/s12915-022-01316-0.

Claire Palles, Hannah D West, Edward Chew, Sara Galavotti, Christoffer Flensburg, Judith E Grolleman, Erik AM Jansen, Helen Curley, Laura Chegwidden, Edward H Arbe-Barnes, Nicola Lander, Rebecca Truscott, Judith Pagan, Ashish Bajel, Kitty Sherwood, Lynn Martin, Huw Thomas, Demetra Georgiou, Florentina Fostira, Yael Goldberg, David J Adams, Simone A M van der Biezen, Michael Christie, Mark Clendenning, Laura E Thomas, Constantinos Deltas, Aleksandar J Dimovski, Dagmara Dymerska, Jan Lubinski, Khalid Mahmood, Rachel S van der Post, Mathijs Sanders, Jurgen Weitz, Jenny C Taylor, Clare Turnbull, Lilian Vreede, Tom van Wezel, Celina Whalley, Claudia Arnedo-Pac, Giulio Caravagna, William Cross, Daniel Chubb, Anna Frangou, Andreas J Gruber, Ben Kinnersley, Boris Noyvert, David Church, Trevor Graham, Richard S Houlston, Nuria Lopez-Bigas, Andrea Sottoriva, David C Wedge, Genomics England Research Consortium, The CORGI Consortium, WGS500 Consortium, Mark A Jenkins, Roland P Kuiper, Andrew W Roberts, Jeremy P Cheadle, Morjolijn J L Ligtenberg, Nicoline Hoogerbrugge, Viktor H Koelzer, Andres Dacal Rivas, Ingrid M Winship, Clara Ruiz Ponte, Daniel D Buchanan, Derek G Power, Andrew Green, Ian P M Tomlinson, Julian R Sampson, Ian J Majewski, Richarda M de Voer (2022). Germline MBD4 Deficiency Causes a Multi-Tumor Predisposition Syndrome. The American Journal of Human Genetics, 109(5) 953–960. Elsevier https://doi.org/10.1016/j.ajhg.2022.03.018.

Annalise C Katz-Summercorn, Sriganesh Jammula, Anna Frangou, Iliana Peneva, Maria O'Donovan, Monika Tripathi, Shalini Malhotra, Massimiliano di Pietro, Sujath Abbas, Ginny Devonshire, Wladyslaw Januszewicz, Adrienn Blasko, Karol Nowicki-Osuch, Shona MacRae, Alex Northrop, Aisling M Redmond, David C Wedge, Rebecca C Fitzgerald (2022). Multi-Omic Cross-Sectional Cohort Study of Pre-Malignant Barrett’s Esophagus Reveals Early Structural Variation and Retrotransposon Activity. Nature communications, 13(1) 1–17. Nature Publishing Group https://doi.org/10.1038/s41467-022-28237-4.

Natalia Garcia Martin, Stefano Malacrino, Marta Wojciechowska, Leticia Campo, Helen Jones, David C Wedge, Chris Holmes, Korsuk Sirinukunwattana, Heba Sailem, Clare Verrill, Jens Rittscher (2022). A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples. (arXiv:2202.00813) arXiv https://doi.org/10.48550/arXiv.2202.00813.

Daniel P Cooke, David C Wedge, Gerton Lunter (2021). Benchmarking Small-Variant Genotyping in Polyploids. Genome research, 32(2) 403–408. Cold Spring Harbor Lab https://doi.org/10.1101/gr.275579.121.

Joe S Lee, Nicholas Williams, Joanna E Baxter, Anna L Godfrey, Kate Milne, Karim Mane, David C Wedge, Peter J Campbell, Anthony R Green, Jyoti Nangalia (2021). Changes in Clonal Architecture Inform MPN Disease Course in Advance of Phenotypic Manifestations. Blood, 138 3590. Elsevier https://doi.org/10.1182/blood-2021-152436.

Annalise Katz-Summercorn, Sriganesh Jammula, Anna Frangou, Iliana Peneva, Maria O'Donovan, Monika Tripathi, Shalini Malhotra, Massimiliano di Pietro, Shujath Abbas, Ginny Devonshire, Wladyslaw Januszewicz, Adrienn Blasko, Karol Nowicki-Osuch, Shona MacRae, Alex Northrop, Aisling M Redmond, David C Wedge, Rebecca C Fitzgerald (2021). P-OGC44 Multi-Omic Cohort Study of Barrett’s Oesophagus Reveals Structural Variation and Retrotransposon Activity to Occur Early in Cancer Evolution. British Journal of Surgery, 108(9) znab430–172. Oxford University Press https://doi.org/10.1093/bjs/znab430.172.

Naser Ansari-Pour, Yonglan Zheng, Toshio F Yoshimatsu, Ayodele Sanni, Mustapha Ajani, Jean-Baptiste Reynier, Avraam Tapinos, Jason J Pitt, Stefan Dentro, Anna Woodard, Padma Sheila Rajgopal, Dominic Fitzgerald, Andreas J Gruber, Abayomi Odetunde, Abiodun Popoola, Adeyinka G Falusi, Chinedum Peace Babalola, Temidayo Ogundiran, Nasiru Ibrahim, Jordi Barretina, Peter Van Loo, Mengjie Chen, Kevin P White, Oladosu Ojengbede, John Obafunwa, Dezheng Huo, David C Wedge, Olufunmilayo I Olopade (2021). Whole-Genome Analysis of Nigerian Patients with Breast Cancer Reveals Ethnic-Driven Somatic Evolution and Distinct Genomic Subtypes. Nature Communications, 12(1) Nature Publishing Group https://doi.org/10.1038/s41467-021-27079-w.

Kirsi Ketola, Heidi Kaljunen, Sinja Taavitsainen, Roosa Kaarijarvi, Emmi Jarvela, Bernardo Rodriguez Martin, Kerstin Haase, Dan J Woodcock, Jose Tubio, David C Wedge, Matti Nykter, G Steven Bova (2021). Subclone Eradication Analysis Identifies Targets for Enhanced Cancer Therapy and Reveals L1 Retrotransposition as a Dynamic Source of Cancer Heterogeneity. Cancer Research, 81(19) 4901–4909. American Association for Cancer Research https://doi.org/10.1158/0008-5472.CAN-21-0371.

Naser Ansari-Pour, Silvia Salatino, Nicola Weston-Bell, Dean Bryant, Luz Yurany Moreno, Angelo Vacca, Niklas Zojer, Andrew Zannettino, Rory Bowden, David C Wedge, Surinder Sahota (2021). P-061: Single-Cell Whole-Exome DNA Sequencing Traces Clonal Trajectory in Paired Evolution of MGUS to Multiple Myeloma. Clinical Lymphoma, Myeloma and Leukemia, 21 S72. Elsevier https://doi.org/10.1016/S2152-2650(21)02195-9.

Tongwu Zhang, Philippe Joubert, Naser Ansari-Pour, Wei Zhao, Phuc H Hoang, Rachel Lokanga, Aaron L Moye, Jennifer Rosenbaum, Abel Gonzalez-Perez, Francisco Martinez-Jimenez, Andrea Castro, Lucia Anna Muscarella, Paul Hofman, Dario Consonni, Angela C Pesatori, Michael Kebede, Mengying Li, Bonnie E Gould Rothberg, Iliana Peneva, Matthew B Schabath, Maria Luana Poeta, Manuela Constantini, Daniela Hirsch, Kerstin Heselmeyer-Haddad, Amy Hutchinson, Mary Olanich, Scott M Lawrence, Petra Lenz, Maire Duggan, Praphulla M S Bhawsar, Jian Sang, Jung Kim, Laura Mendoza, Natalie Saini, Leszek J Klimczak, SM Ashiqul Islam, Burcak Otlu, Azhar Khandekar, Nathan Cole, Douglas R Stewart, Jiyeon Choi, Kevin M Brown, Neil E Caporaso, Samuel H Wilson, Yves Pommier, Qing Lan, Nathaniel Rothman, Jonas S Almeida, Hannah Carter, Thomas Ried, Carla F Kim, Nuria Lopez-Bigas, Montserrat Garcia-Closas, Jianxin Shi, Yohan Bosse, Bin Zhu, Dmitry A Gordenin, Ludmil B Alexandrov, Stephen J Chanock, David C Wedge, Maria Teresa Landi (2021). Genomic and Evolutionary Classification of Lung Cancer in Never Smokers. Nature genetics, 53(9) 1348–1359. Nature Publishing Group https://doi.org/10.1038/s41588-021-00920-0.

Dana Pe'er, Seishi Ogawa, Ofer Elhanani, Leeat Keren, Trudy G Oliver, David C Wedge (2021). Tumor Heterogeneity. Cancer cell, 39(8) 1015–1017. Elsevier https://doi.org/10.1016/j.ccell.2021.07.009.

Maria Teresa Landi, Naoise C Synnott, Jennifer Rosenbaum, Tongwu Zhang, Bin Zhu, Jianxin Shi, Wei Zhao, Michael Kebede, Jian Sang, Jiyeon Choi, Laura Mendoza, Marwil Pacheco, Belynda Hicks, Neil E Caporaso, Mustapha Abubakar, Dmitry A Gordenin, David C Wedge, Ludmil B Alexandrov, Nathaniel Rothman, Qing Lan, Montserrat Garcia-Closas, Stephen J Chanock (2021). Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers: The Sherlock-Lung Study. American Journal of Epidemiology, 190(6) 962–976. Oxford University Press https://doi.org/10.1093/aje/kwaa234.

Daniel Cooke, Gerton Lunter, David C Wedge (2021). Accurate Genotyping of Single Cells with Octopus. ResearchSquare https://doi.org/10.21203/rs.3.rs-583831/v1.

Mick D Brown, Claire Hart, Ashwin Sachdeva, Pedro Oliveira, Christian D Fankhauser, David C Wedge, Noel W Clarke (2021). P0427 - Localised Activation of the EMT Switch by Peri-Neural Invading Epithelial Cells in Prostate Cancer. European Urology, 79(S1) https://doi.org/10.1016/S0302-2838(21)00810-1.

Andrew Erickson, Alicia Hayes, Timothy Rajakumar, Clare Verrill, Richard J Bryant, Freddie C Hamdy, David C Wedge, Dan J Woodcock, Ian G Mills, Alastair D Lamb (2021). A Systematic Review of Prostate Cancer Heterogeneity: Understanding the Clonal Ancestry of Multifocal Disease. European Urology Oncology, 4(3) 358–369. Elsevier https://doi.org/10.1016/j.euo.2021.02.008.

Claire Palles, Edward Chew, Judith E Grolleman, Sara Galavotti, Christoffer Flensburg, Erik AM Jansen, Helen Curley, Laura Chegwidden, Edward Arbe Barnes, Ashish Bajel, Kitty Sherwood, Lynn Martin, Huw Thomas, Demetra Georgiou, Florentina Fostira, Yael Goldberg, David J Adams, Simone A M van der Biezen, Michael Christie, Mark Clendenning, Constantinos Deltas, Aleksandar J Dimovski, Dagmara Dymerska, Jan Lubinski, Khalid Mahmood, Rachel S van der Post, Mathijs Sanders, Jurgen Weitz, Jenny C Taylor, Clare Turnbull, Lilian Vreede, Tom van Wezel, Celina Whalley, Claudia Arnedo-Pac, Giulio Caravagna, William Cross, Daniel Chubb, Anna Frangou, Andreas Gruber, Ben Kinnersley, Boris Noyvert, David Church, Trevor Graham, Richard S Houlston, Nuria Lopez-Bigas, Andrea Sottoriva, David C Wedge, Genomics England Research Consortium, The CORGI Consortium, WGS500 Consortium, Mark A Jenkins, Roland P Kuiper, Andrew W Roberts, Morjolijn J L Ligtenberg, Nicoline Hoogerbrugge, Viktor H Koelzer, Andres Dacal Rivas, Ingrid M Winship, Clara Ruiz Ponte, Daniel D Buchanan, Ian P M Tomlinson, Ian J Majewski, Richarda M de Voer (2021). Germline Loss-of-Function Variants in the Base-Excision Repair Gene MBD4 Cause a Mendelian Recessive Syndrome of Adenomatous Colorectal Polyposis and Acute Myeloid Leukaemia. BioRxiv Cold Spring Harbor Laboratory https://doi.org/10.1101/2021.04.27.441137.

Stefan C Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G Deshwar, Kaixian Yu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vazquez Garcia, Kortine Kleinheinz, Dimitri G Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E Schumacher, Yu Fan, Matthew Fittall, Ruben M Drews, Xiaotong Yao, Thomas B K Watkins, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J Adams, Nicholas McGranahan, Charles Swanton, Gad Getz, Paul C Boutros, Marcin Imielinski, Rameen Beroukhim, S Cenk Sahinalp, Yuan Ji, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Paul T Spellman, Wenyi Wang, Quaid D Morris, David C Wedge, Peter Van Loo (2021). Characterizing Genetic Intra-Tumor Heterogeneity across 2,658 Human Cancer Genomes. Cell, 184(8) 2239–2254. Elsevier https://doi.org/10.1016/j.cell.2021.03.009.

Matteo Morotti, Ashwag Albukhari, Abdulkhaliq Alsaadi, Mara Artibani, James D Brenton, Stuart M Curbishley, Tao Dong, Michael L Dustin, Zhiyuan Hu, Nicholas McGranahan, Martin L Miller, Laura Santana-Gonzalez, Leonard W Seymour, Tingyan Shi, Peter Van Loo, Christopher Yau, Helen White, Nina Wietek, David Church, David C Wedge, Ahmed A Ahmed (2021). Promises and Challenges of Adoptive T-Cell Therapies for Solid Tumours. British journal of cancer, 124(11) 1759–1776. Nature Publishing Group https://doi.org/10.1038/s41416-021-01353-6.

Daniel P Cooke, David C Wedge, Gerton Lunter (2021). A Unified Haplotype-Based Method for Accurate and Comprehensive Variant Calling. Nature biotechnology, 39(7) 885–892. Nature Publishing Group https://doi.org/10.1038/s41587-021-00861-3.

Mohieddin Jafari, Yuanfang Guan, David C Wedge, Naser Ansari-Pour (2021). Re-Evaluating Experimental Validation in the Big Data Era: A Conceptual Argument. Genome Biology, 22(1) 1–6. https://doi.org/10.1186/s13059-021-02292-4.

Mick D Brown, Claire Alexandre Hart, Ashwin Sachdeva, Christian Faulkner, David C Wedge, Noel W Clarke (2021). Abstract: Localized Activation of the Metastatic Phenotype within the Perineural Region in Prostate Cancer.. Journal of Clinical Oncology https://doi.org/DOI: 10.1200/JCO.2021.39.6_suppl.253.

Maxime Tarabichi, Adriana Salcedo, Amit G Deshwar, Maire Ni Leathlobhair, Jeff Wintersinger, David C Wedge, Peter Van Loo, Quaid D Morris, Paul C Boutros (2021). A Practical Guide to Cancer Subclonal Reconstruction from DNA Sequencing. Nature methods, 18(2) 144–155. Nature Publishing Group https://doi.org/10.1038/s41592-020-01013-2.

Young Mi Kwon, Kevin Gori, Naomi Park, Nicole Potts, Kate Swift, Jinhong Wang, Maximilian R Stammnitz, Naomi Cannell, Adrian Baez-Ortega, Sebastien Comte, Samantha Fox, Colette Harmsen, Stewart Huxtable, Menna Jones, Alexandre Kreiss, Clare Lawrence, Billie Lazenby, Sarah Peck, Ruth Pye, Gregory Woods, Mona Zimmerman, David C Wedge, David Pemberton, Michael R Stratton, Rodrigo Hamede, Elizabeth P Murchison (2020). Evolution and Lineage Dynamics of a Transmissible Cancer in Tasmanian Devils. PLoS biology, 18(11) e3000926. Public Library of Science San Francisco, CA USA https://doi.org/10.1371/journal.pbio.3000926.

Maria Teresa Landi, Naoise C Synnott, Jennifer Rosenbaum, Tongwu Zhang, Bin Zhu, Jianxin Shi, Wei Zhao, Michael Kebede, Jian Sang, Jiyeon Choi, Laura Mendoza, Marwil Pacheco, Belynda Hicks, Neil E Caporaso, Mustapha Abubakar, Dmitry A Gordenin, David C Wedge, Ludmil B Alexandrov, Nathaniel Rothman, Qing Lan, Montserrat Garcia-Closas, Stephen J Chanock (2020). Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study. American Journal of Epidemiology, 190(6) 962–976. https://doi.org/10.1093/aje/kwaa234.

Dan J Woodcock, Ekaterina Riabchenko, Sinja Taavitsainen, Matti Kankainen, Gunes Gundem, elax DS Brewer, Pekka Ellonen, Maija Lepisto, elax YA Golubeva, elax AC Warner, T Tolonen, J Jasu, William B Isaacs, Michael R Emmert-Buck, Matti Nykter, T Visakorpi, G Steven Bova, David C Wedge (2020). Prostate Cancer Evolution from Multilineage Primary to Single Lineage Metastases with Implications for Liquid Biopsy. Nature communications, 11(1) 1–13. Nature Publishing Group https://doi.org/10.1038/s41467-020-18843-5.

Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, PCAWG Tumour Subtypes, linical Translation, PCAWG Consortium, Paul C Boutros (2020). Sex Differences in Oncogenic Mutational Processes. Nature communications, 11(1) Nature Publishing Group https://doi.org/10.1038/s41467-020-17359-2.

Matthew H Bailey, William U Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, MC3 Working Group, PCAWG novel somatic mutation calling methods working group, Gordon Saksena, Kyle Ellrott, Michael C Wendl, David A Wheeler, Gad Getz, Jared T Simpson, Mark B Gerstein, Li Ding, PCAWG Consortium (2020). Retrospective Evaluation of Whole Exome and Genome Mutation Calls in 746 Cancer Samples. Nature communications, 11(1) Nature Publishing Group https://doi.org/10.1038/s41467-020-18151-y.

Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M Martinez Gomez, Mitchell Levesque, Ferdia A Gallagher, Alejandro Jimenez-Sanchez, Laura Riva, Martin L Miller, Kieren Allinson, Peter J Campbell, Pippa Corrie, David C Wedge, David J Adams (2020). Multi-Site Clonality Analysis Uncovers Pervasive Heterogeneity across Melanoma Metastases. Nature communications, 11(1) Nature Publishing Group https://doi.org/10.1038/s41467-020-18060-0.

Soulafa Mamlouk, Tincy Simon, Laura Tomas, David C Wedge, Alexander Arnold, Andrea Menne, David Horst, David Capper, Markus Morkel, David Posada, Christine Sers, Hendrik Blaker (2020). Malignant Transformation and Genetic Alterations Are Uncoupled in Early Colorectal Cancer Progression. BMC biology, 18(1) Springer https://doi.org/10.1186/s12915-020-00844-x.

Sarah Killcoyne, Eleanor Gregson, David C Wedge, Dan J Woodcock, Matthew D Eldridge, Rachel de la Rue, Ahmad Miremadi, Sujath Abbas, Adrienn Blasko, Cassandra Kosmidou, Wladyslaw Januszewicz, Aikaterini Varanou Jenkins, Moritz Gerstung, Rebecca C Fitzgerald (2020). Genomic Copy Number Predicts Esophageal Cancer Years before Transformation. Nature medicine, 26(11) 1726–1732. Nature Publishing Group https://doi.org/10.1038/s41591-020-1033-y.

Andrew M Erickson, Alicia Hayes, Catherine Lovegrove, Lois Vesty-Edwards, Dan J Woodcock, Richard J Bryant, Freddie C Hamdy, David C Wedge, Ian G Mills, Alastair D Lamb (2020). Harnessing the Power of RNA in Determining the Origin of Lethal Micro-Metastatic Prostate Cancer. European Urology Open Science, 19 e664. Elsevier https://doi.org/10.1016/S2666-1683(20)33015-9.

Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Wei Zhao, Vincenzo Pompeo, Maurizio Cardelli, Boian S Alexandrov, Burcak Otlu, Xing Hua, Kristine Jones, Seth Brodie, Malgorzata Ewa Dabrowska, Jorge R Toro, Meredith Yeager, Mingyi Wang, Belynda Hicks, Ludmil B Alexandrov, Kevin M Brown, David C Wedge, Stephen J Chanock, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi (2020). The Genomic and Epigenomic Evolutionary History of Papillary Renal Cell Carcinomas. Nature communications, 11(1) Nature Publishing Group https://doi.org/10.1038/s41467-020-16546-5.

Alex J Cornish, Daniel Chubb, Anna Frangou, Phuc H Hoang, Martin Kaiser, David C Wedge, Richard S Houlston (2020). Reference Bias in the Illumina Isaac Aligner. Bioinformatics, 36(17) 4671–4672. Oxford University Press https://doi.org/10.1093/bioinformatics/btaa514.

Xing Hua, Wei Zhao, Angela C Pesatori, Dario Consonni, Neil E Caporaso, Tongwu Zhang, Bin Zhu, Mingyi Wang, Kristine Jones, Belynda Hicks, Lei Song, Joshua Sampson, David C Wedge, Jianxin Shi, Maria Teresa Landi (2020). Genetic and Epigenetic Intratumor Heterogeneity Impacts Prognosis of Lung Adenocarcinoma. Nature communications, 11(1) 1–11. Nature Publishing Group https://doi.org/10.1038/s41467-020-16295-5.

Srinivasa R Rao, Nasullah K Alham, Elysia Upton, Stacey McIntyre, Richard J Bryant, Lucia Cerundolo, Emma Bowes, Stephanie Jones, Molly Browne, Ian Mills, Alastair D Lamb, Ian P M Tomlinson, David C Wedge, Lisa Browning, Korsuk Sirinukunwattana, Claire Palles, Freddie C Hamdy, Jens Rittscher, Clare Verrill (2020). Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2: ERG Fusion Status and Immune Cell Infiltration. The Journal of Molecular Diagnostics, 22(5) 652–669. Elsevier https://doi.org/10.1016/j.jmoldx.2020.02.012.

David Wedge (2020). Characterizing Genetic Intra-Tumor Heterogeneity Across 2,658 Human Cancer Genomes.

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Arne V Pladsen, Gro Nilsen, Oscar M Rueda, Miriam R Aure, Ornulf Borgan, Knut Liestol, Valeria Vitelli, Arnoldo Frigessi, Anita Langerod, Anthony Mathelier, OSBREAC, Olav Engebraten, Vessela Kristensen, David C Wedge, Peter Van Loo, Carlos Caldas, Anne-Lise Borresen-Dale, Hege G Russnes, Ole Christian Lingjaerde (2020). DNA Copy Number Motifs Are Strong and Independent Predictors of Survival in Breast Cancer. Communications biology, 3(1) 1–9. Nature Publishing Group https://doi.org/10.1038/s42003-020-0884-6.

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C Dentro, Santiago Gonzalez, Daniel Rosebrock, Thomas J Mitchell, Yulia Rubanova, Pavana Anur, Kaixian Yu, Maxime Tarabichi, Amit Deshwar, Jeff Wintersinger, Kortine Kleinheinz, Ignacio Vazquez Garcia, Kerstin Haase, Lara Jerman, Subhajit Sengupta, Geoff Macintyre, Salem Malikic, Nilgun Donmez, Dimitri G Livitz, Marek Cmero, Jonas Demeulemeester, Steven Schumacher, Yu Fan, Xiaotong Yao, Juhee Lee, Matthias Schlesner, Paul C Boutros, David D Bowtell, Hongtu Zhu, Gad Getz, Marcin Imielinski, Rameen Beroukhim, S Cenk Sahinalp, Yuan Ji, Martin Peifer, Florian Markowetz, Ville Mustonen, Ke Yuan, Wenyi Wang, Quaid D Morris, PCAWG Evolution & Heterogeneity Working Group, Paul T Spellman, David C Wedge, Peter Van Loo, PCAWG Consortium (2020). The Evolutionary History of 2,658 Cancers. Nature, 578(7793) 122–128. Nature Publishing Group https://doi.org/10.1038/s41586-019-1907-7.

David Wedge (2020). The evolutionary history of 2,658 cancers. In Nature.

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The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (2020). Pan-Cancer Analysis of Whole Genomes.. Nature, 578 82–93. W190 Hochdurchsatz-Sequenzierung https://doi.org/10.1038/s41586-020-1969-6.

David Wedge (2020). Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. In Nat Gen.

PDF Project DOI Article

Adriana Salcedo, Maxime Tarabichi, Shadrielle Melijah G Espiritu, Amit G Deshwar, Matei David, Nathan M Wilson, Stefan Dentro, Jeff A Wintersinger, Lydia Y Liu, Minjeong Ko, Srinivasan Sivanandan, Hongjui Zhang, Kaiyi Zhu, Tai-Hsien Ou Yang, John M Chilton, Alex Buchanan, Christopher M Lalansingh, Christine P'ng, Catalina V Anghel, Imaad Umar, Bryan Lo, William Zou, DREAM SMC-Het Participants, Jared T Simpson, Joshua M Stuart, Dimitris Anastassiou, Yuanfang Guan, Adam D Ewing, Kyle Ellrott, David C Wedge, Quaid D Morris, Peter Van Loo, Paul C Boutros (2020). A Community Effort to Create Standards for Evaluating Tumor Subclonal Reconstruction. Nature biotechnology, 38(1) 97–107. Nature Publishing Group https://doi.org/10.1038/s41587-019-0364-z.

Ayesha Noorani, Xiaodun Li, Martin Goddard, Jason Crawte, Ludmil B Alexandrov, Maria Secrier, Matthew D Eldridge, Lawrence Bower, Jamie Weaver, Pierre Lao-Sirieix, Inigo Martincorena, Irene Debiram-Beecham, Nicola Grehan, Shona MacRae, Shalini Malhotra, Ahmad Miremadi, Tabitha Thomas, Sarah Galbraith, Lorraine Petersen, Stephen D Preston, David Gilligan, Andrew Hindmarsh, Richard H Hardwick, Michael R Stratton, David C Wedge, Rebecca C Fitzgerald (2020). Genomic Evidence Supports a Clonal Diaspora Model for Metastases of Esophageal Adenocarcinoma. Nature genetics, 52(1) 74–83. Nature Publishing Group https://doi.org/10.1038/s41588-019-0551-3.

Tim HH Coorens, Taryn D Treger, Reem Al-Saadi, Luiza Moore, Maxine GB Tran, Thomas J Mitchell, Suzanne Tugnait, Christine Thevanesan, Matthew D Young, Thomas RW Oliver, Minou Oostveen, Grace Collord, Patrick S Tarpey, Alex Cagan, Yvette Hooks, Mark Brougham, Ben C Reynolds, Giuseppe Barone, John Anderson, Mette Jorgensen, G A Amos Burke, Johannes Visser, James C Nicholson, Naima Smeulders, Imran Mushtaq, Grant D Stewart, Peter J Campbell, David C Wedge, Inigo Martincorena, Dyanne Rampling, Liz Hook, Anne Y Warren, Nicholas Coleman, Tanzina Chowdhury, Neil Sebire, Jarno Drost, Kourosh Saeb-Parsy, Michael R Stratton, Karin Straathof, Kathy Pritchard-Jones, Sam Behjati (2019). Embryonal Precursors of Wilms Tumor. Science, 366(6470) 1247–1251. American Association for the Advancement of Science https://doi.org/10.1126/science.aax1323.

Alex J Cornish, Daniel Chubb, Anna Frangou, Phuc H Hoang, Martin Kaiser, David C Wedge, Richard S Houlston (2019). Correcting Reference Bias from the Illumina Isaac Aligner Enables Analysis of Cancer Genomes. bioRxiv 836171. Cold Spring Harbor Laboratory https://doi.org/10.1101/836171.

Laura Mendoza, Tongwu Zhang, Montserrat Garcia-Closas, Abubakar Abubakar Mustapha, Oscar Arrieta, Paul Hofman, David Christiani, Nuria Lopez-Bigas, Bonnie E Gould Rothberg, Tobias Peikert, Dmitry A Gordenin, Ludmil B Alexandrov, Gad Getz, David C Wedge, Maria Teresa Landi (2019). P1. 08-A Sherlock Lung Tracing Lung Cancer Mutational Processes in Never-Smokers. Journal of Thoracic Oncology, 14(11) S1176–S1177. Elsevier https://doi.org/10.1016/j.jtho.2019.09.143.

Anna Frangou, Alex J Cornish, Ben Kinnersley, David C Wedge, Andrew Protheroe, Matthew J Murray, Clare Verrill (2019). GCT-21 - Testicular Cancer Genomics England Clinical Interpretation Partnership (GECIP): A Genomic Exploration of Testicular Germ Cell Tumours. European Urology Supplements, 18(4) 12–13. Elsevier https://doi.org/10.1016/S1569-9056(19)32488-1.

Francesco Maura, Niccolo Bolli, Nicos Angelopoulos, Kevin J Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas J Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodriguez Martin, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu-Tzu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth C Anderson, Jose M C Tubio, David C Wedge, Moritz Gerstung, Herve Avet-Loiseau, Nikhil Munshi, Peter J Campbell (2019). Genomic Landscape and Chronological Reconstruction of Driver Events in Multiple Myeloma. Nature communications, 10(1) 1–12. Nature Publishing Group https://doi.org/10.1038/s41467-019-11680-1.

Bradley A Hancock, Yu-Hsiang Chen, Jeffrey P Solzak, Mufti N Ahmad, David C Wedge, Dumitru Brinza, Charles Scafe, James Veitch, Rajesh Gottimukkala, Walt Short, Rutuja V Atale, Mircea Ivan, Sunil S Badve, Bryan P Schneider, Xiongbin Lu, Kathy D Miller, Milan Radovich (2019). Profiling Molecular Regulators of Recurrence in Chemorefractory Triple-Negative Breast Cancers. Breast cancer research, 21(1) Springer https://doi.org/10.1186/s13058-019-1171-7.

Maria Teresa Landi, Tongwu Zhang, Montserrat Garcia-Closas, Yohan Bosse, Jianxin Shi, Bin Zhu, Qing Lan, Nathaniel Rothman, Jiyeon Choi, Neil E Caporaso, Wei Zhao, Chongyi Chen, Eytan Ruppin, Jennifer Rosenbaum, Dmitry A Gordenin, Sai Yendamuri, Chris Amos, Paul Brennan, David Christiani, Geoff Liu, Bonnie Gould Rothberg, Matthew Schabath, Han Liang, Ludmil B Alexandrov, David C Wedge, Stephen J Chanock (2019). Abstract SY26-02: Sherlock-Lung: Tracing Lung Cancer Mutational Processes in Never Smokers. Cancer Research, 79(13) SY26–02. AACR https://doi.org/10.1158/1538-7445.AM2019-SY26-02.

Naser Ansari-Pour, Jason J Pitt, Stefan Dentro, Dominic Fitzgerald, Yonglan Zheng, Toshio F Yoshimatsu, Padma Rajagopal, Andreas Gruber, Ayodele Sanni, Olayiwola Oluwasola, Mustapha Ajani, Abayomi Odetunde, Abiodun Popoola, Adeyinka G Falusi, Temidayo Ogundiran, John Obafunwa, Oladosu Ojengbede, Nasiru Ibrahim, Kevin P White, Dezheng Huo, Peter Van Loo, David C Wedge, Olufunmilayo I Olopade (2019). Abstract LB-300: The Life History of Breast Cancer in Nigerian Women: Evidence for Ethnic Differences in Tumor Evolution Based on Whole-Genome Sequencing. Cancer Research, 79(13) LB–300. AACR https://doi.org/10.1158/1538-7445.AM2019-LB-300.

Mia Petljak, Ludmil B Alexandrov, Jonathan S Brammeld, Stacey Price, David C Wedge, Sebastian Grossmann, Kevin J Dawson, Young Seok Ju, Francesco Iorio, Jose MC Tubio, Ching Chiek Koh, Ilias Georgakopoulos-Soares, Bernardo Rodriguez Martin, Burcak Otlu, Sarah O'Meara, Adam P Butler, Andrew Menzies, Shriram G Bhosie, Keiran M Raine, David R Jones, Jon W Teague, Kathryn Beal, Cali Latimer, Laura O'Neill, Jorge Zamora, Elizabeth Andersan, Nikita Patel, Mark Maddison, Bee Ling Ng, Jennifer Graham, Mathew J Garnett, Ultan McDermott, Serena Nik-Zainal, Peter J Campbell, Michael R Stratton (2019). Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis. Cell, 176(6) 1282–1294. Elsevier https://doi.org/10.1016/j.cell.2019.02.012.

elax WCH Cross, G Caravagna, J Houseman, A Sosinsky, N Murugaesu, Daniel Chubb, Alex J Cornish, David C Wedge, Richard S Houlston, Andrea Sottoriva, Trevor A Graham, Ian P M Tomlinson (2019). The Preliminary Results from the 100,000 Genomes Project: The Genomic Landscape of Colorectal Cancer. Winter Meeting. Abstracts of the 211th Meeting of the Pathological Society of Great Britain and Ireland, 22-23 January 2019, London. , 248 S14–S14. Wiley https://doi.org/10.1002/path.5276.

Elen Kristine Hoglander, Silje Nord, David C Wedge, Ole Christian Lingjaerde, Laxmi Silwal-Pandit, Hans Kristian Moen Vollan, Thomas Fleischer, Marit Krohn, Ellen Schlitchting, Elin Borgen, Oystein Garred, Marit M Holmen, Erik Wist, Bjorn Naume, Peter Van Loo, Anne-Lise Borresen-Dale, Olav Engebraten, Vessela Kristensen (2018). Time Series Analysis of Neoadjuvant Chemotherapy and Bevacizumab-Treated Breast Carcinomas Reveals a Systemic Shift in Genomic Aberrations. Genome medicine, 10(1) 1–14. BioMed Central https://doi.org/10.1186/s13073-018-0601-y.

Maxime Tarabichi, Inigo Martincorena, Moritz Gerstung, Armand M Leroi, Florian Markowetz, The PCAWG Evolution, eterogeneity Working Group, Paul T Spellman, Quaid D Morris, Ole Christian Lingjaerde, David C Wedge, Peter Van Loo (2018). Neutral Tumor Evolution?. Nature genetics, 50(12) 1630–1633. Nature Publishing Group https://doi.org/10.1038/s41588-018-0258-x.

Francesco Maura, Kevin J Dawson, Nicos Angelopoulos, Stephane Minvielle, Inigo Martincorena, Thomas J Mitchell, Anthony Fullam, elax FS Pacciarini Gonzalez, Dominik Glodzik, Raphael Szalat, Mehmet Kemal Samur, Mariateresa Fulciniti, Florence Magrangeas, Philippe Moreau, Kenneth C Anderson, David C Wedge, Moritz Gerstung, Paolo Corradini, Herve Avet-Loiseau, Nikhil Munshi, Peter J Campbell (2018). The Genomic Landscape of Structural Variations and Complex Events in Multiple Myeloma. Italian Society of Experimental Hematology. , 103 S14–S14. Fondazione Ferrata Storti.

Jacob Grinfeld, Jyoti Nangalia, E Joanna Baxter, David C Wedge, Nicos Angelopoulos, Robert Cantrill, Anna L Godfrey, Elli Papaemmanuil, Gunes Gundem, Cathy MacLean, Julia Cook, Laura O'Neill, Sarah O'Meara, Jon W Teague, Adam P Butler, Charles E Massie, Nicholas Williams, Francesca L Nice, Christen Lykkegaard Andersen, Hans Carl Hasselbalch, Paola Guglielmelli, Mary Frances McMullin, Alessandro M Vannucchi, Claire N Harrison, Moritz Gerstung, Anthony R Green, Peter J Campbell (2018). Classification and Personalized Prognosis in Myeloproliferative Neoplasms. New England Journal of Medicine, 379(15) 1416–1430. Mass Medical Soc https://doi.org/https://www.doi.org/10.1056/NEJMoa1716614.

Niccolo Bolli, Francesco Maura, Kevin J Dawson, Nicos Angelopoulos, Stephane Minvielle, Inigo Martincorena, Thomas J Mitchell, elax AFS Gonzalez, Dominik Glodzik, Raphael Szalat, Mehmet Kemal Samur, Mariateresa Fulciniti, Yu-Tzu Tai, Florence Magrangeas, Philippe Moreau, Kenneth Anderson, David C Wedge, Moritz Gerstung, Paolo Corradini, Herve Avet-Loiseau, Nikhil Munshi, Peter J Campbell (2018). Analysis of Mutations and Structural Variants to Redefine the Genomic Landscape of Multiple Myeloma and Its Clinical Implications. Italian Society of Experimental Hematology. , 103 S51–S51. Fondazione Ferrata Storti.

William Cross, Michal Kovac, Ville Mustonen, Daniel Temko, Hayley Davis, Ann-Marie Baker, Sujata Biswas, Roland Arnold, Laura Chegwidden, Chandler Gatenbee, Alexander R Anderson, Viktor H Koelzer, Pierre Martinez, Xiaowei Jiang, Enric Domingo, Dan J Woodcock, Yun Feng, Monika Kovacova, Tim Maughan, The S:CORT Consortium, Marnix Jansen, Manuel Rodriguez-Justo, Shazad Ashraf, Richard Guy, Christopher Cunningham, James E East, David C Wedge, Lai Mun Wang, Claire Palles, Karl Heinimann, Andrea Sottoriva, Simon J Leedham, Trevor A Graham, Ian P M Tomlinson (2018). The Evolutionary Landscape of Colorectal Tumorigenesis. Nature ecology & evolution, 2(10) 1661–1672. Nature Publishing Group https://doi.org/10.1038/s41559-018-0642-z.

Niccolo Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Kevin J Dawson, Mehmet Kemal Samur, Jorge Zamora, Patrick Tarpey, Helen Davies, Mariateresa Fulciniti, Masood A Shammas, Yu-Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Ludmil B Alexandrov, David C Wedge, Herve Avet-Loiseau, Peter J Campbell, Nikhil Munshi (2018). Genomic Patterns of Progression in Smoldering Multiple Myeloma. Nature communications, 9(1) 1–10. Nature Publishing Group https://doi.org/10.1038/s41467-018-05058-y.

Xiaodun Li, Hayley E Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Nuria Galeano-Dalmau, William J Barendt, Laura Letchford, Genevieve M Leyden, Emma K Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C Wedge, Rebecca C Fitzgerald, Mathew J Garnett (2018). Organoid Cultures Recapitulate Esophageal Adenocarcinoma Heterogeneity Providing a Model for Clonality Studies and Precision Therapeutics. Nature communications, 9(1) 1–13. Nature Publishing Group https://doi.org/10.1038/s41467-018-05190-9.

Stefan Dentro, Ignaty Leshchiner, Kerstin Haase, Jeff Wintersinger, Amit Deshwar, Maxime Tarabichi, Yulia Rubanova, Kaixian Yu, Ignacio Vazquez Garcia, Geoff Macintyre, Kortine Kleinheinz, Dimitri G Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Yuan Ji, Jonas Demeulemeester, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E Schumacher, Yu Fan, Matthew Fittall, Xiaotong Yao, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J Adams, Gad Getz, Paul C Boutros, Marcin Imielinski, Rameen Beroukhim, S Cenk Sahinalp, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Wenyi Wang, Paul T Spellman, Quaid D Morris, David C Wedge, Peter Van Loo (2018). Abstract 3000: Pervasive Intra-Tumour Heterogeneity and Subclonal Selection across Cancer Types. Cancer Research, 78(13) 3000–3000. AACR https://doi.org/10.1158/1538-7445.AM2018-3000.

Maxime Tarabichi, Inigo Martincorena, Moritz Gerstung, Florian Markowetz, Paul T Spellman, Quaid D Morris, Ole Christian Lingjaerde, David C Wedge, Peter Van Loo, WG PCAWG (2018). PO-329 Rejecting Neutral Tumour Evolution across Human Cancer Types. ESMO Open, 3 A357. Elsevier https://doi.org/10.1136/esmoopen-2018-EACR25.842.

Soulafa Mamlouk, Tincy Simon, David C Wedge, Markus Morkel, David Capper, H Blaeker, Christine Sers (2018). PO-322 Multi-Region Deep Sequencing of Colorectal Carcinoma in-Situ Defines Oncogenic Transformation as a Gradual and Adaptive Process. ESMO Open, 3 A147. Elsevier https://doi.org/10.1136/esmoopen-2018-EACR25.352.

Kerstin Haase, Stefan C Dentro, Ignaty Leshchiner, Jeff Wintersinger, Amit Deshwar, Maxime Tarabichi, Quaid D Morris, David C Wedge, Peter Van Loo, PCAWG Evolution, eterogeneity Working Group (2018). 33 PAN-Cancer Whole Genome Sequencing Reveals Patterns of Subclonal Mutations, Signature Changes and Selection. ESMO Open, 3 A15. Elsevier https://doi.org/10.1136/esmoopen-2018-EACR25.33.

David C Wedge, Gunes Gundem, Thomas Mitchell, Dan J Woodcock, Inigo Martincorena, Mohammed Ghori, Jorge Zamora, Adam Butler, Hayley Whitaker, Zsofia Kote-Jarai, Ludmil B Alexandrov, Peter Van Loo, Charlie E Massie, Stefan Dentro, Anne Y Warren, Clare Verrill, Dan M Berney, Nening Dennis, Sue Merson, Steve Hawkins, William Howat, Yong-Jie Lu, Adam Lambert, Jonathan Kay, Barbara Kremeyer, Katalin Karaszi, Hayley Luxton, Niedzica Camacho, Luke Marsden, Sandra Edwards, Lucy Matthews, Valeria Bo, Daniel Leongamornlert, Stuart McLaren, Anthony Ng, Yongwei Yu, Hongwei Zhang, Tokhir Dadaev, Sarah Thomas, Douglas F Easton, Mahbubl Ahmed, Elizabeth Bancroft, Cyril Fisher, Naomi Livni, David Nicol, Simon Tavare, Pelvender Gill, Christopher D Greenman, Vincent Khoo, Nicholas Van As, Pardeep Kumar, Christopher Ogden, Declan Cahill, Alan Thompson, Erik Mayer, Edward Rowe, Tim Dudderidge, Vincent Gnanapragasam, Nimish C Shah, Keiran M Raine, David Jones, Andrew Menzies, Lucy A Stebbings, Jon W Teague, Steven Hazell, Cathy Corbishley, CAMCAP Study Group, Johann de Bono, Gerhard Attard, William B Isaacs, Tapio Visakorpi, Michael Fraser, Paul C Boutros, Robert G Bristow, Paul Workman, Chris Sander, The TCGA Consortium, Freddie C Hamdy, Andrew Futreal, Ultan McDermott, Bissan Al-Lazikani, Andrew G Lynch, G Steven Bova, Christopher S Foster, Daniel S Brewer, David E Neal, Colin S Cooper, Rosalind A Eeles (2018). Sequencing of Prostate Cancers Identifies New Cancer Genes, Routes of Progression and Drug Targets. Nature genetics, 50(5) 682–692. Nature Publishing Group https://doi.org/10.1038/s41588-018-0086-z.

Thomas J Mitchell, Samra Turajlic, Andrew Rowan, David Nicol, James HR Farmery, Tim O'Brien, Inigo Martincorena, Patrick Tarpey, Nicos Angelopoulos, Lucy R Yates, Adam P Butler, Keiran M Raine, Grant D Stewart, Ben Challacombe, Archana Fernando, Jose I Lopez, Steven Hazell, Ashish Chandra, Simon Chowdhury, Sarah Rudman, Aspasia Soultati, Gordon Stamp, Nicos Fotiadis, Lisa Pickering, Lewis Au, Lavinia Spain, Joanna Lynch, Mark Stares, Jon W Teague, Francesco Maura, David C Wedge, Stuart Horswell, Tim Chambers, Kevin Litchfield, Hang Xu, Aengus Stewart, Reza Elaidi, Stephane Oudard, Nicholas McGranahan, Istvan Csabai, Martin Gore, P Andrew Futreal, James Larkin, Andrew G Lynch, Zoltan Szallasi, Charles Swanton, Peter J Campbell, The TRACERx Renal Consortium (2018). Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal. Cell, 173(3) 611–623. Elsevier https://doi.org/10.1016/j.cell.2018.02.020.

Bradley A Hancock, Yu-Hsiang Chen, Jeffrey P Solzak, Mufti N Ahmad, David C Wedge, Dumitru Brinza, Charles Scafe, James Veitch, Rajesh Gottimukkala, Walt Short, Rutuja V Atale, Mircea Ivan, Sunil S Badve, Bryan P Schneider, Kathy D Miller, Milan Radovich (2018). Abstract P2-07-04: Molecular Regulators of Resistance and Relapse in Chemorefractory Triple-Negative Breast Cancers. Cancer Research, 78(4) P2–07. AACR https://doi.org/10.1158/1538-7445.SABCS17-P2-07-04.

Bernardo Rodriguez Martin, Eva G Alvarez, Adrian Baez-Ortega, Jorge Zamora, Fran Supek, Jonas Demeulemeester, Martin Santamarina, Young Seok Ju, Javier Temes, Daniel Garcia-Souto, Harald Detering, Yilong Li, Jorge Rodriguez-Castro, Ana Dueso-Barroso, Alicia L Bruzos, Stefan C Dentro, Miguel G Blanco, Gianmarco Contino, Daniel Ardeljan, Marta Tojo, Nicola D Roberts, Sonia Zumalave, Paul A Edwards, Joachim Weischenfeldt, Montserrat Puiggros, Zechen Chong, Ken Chen, Eunjung Alice Lee, Jeremiah A Wala, Keiran M Raine, Adam P Butler, Sebastian M Waszak, Fabio C P Navarro, Steven E Schumacher, Jean Monlong, Francesco Maura, Niccolo Bolli, Guillaume Bourque, Mark B Gerstein, Peter J Park, David C Wedge, Rameen Beroukhim, David Torrents, Jan Korbel, Inigo Martincorena, Rebecca C Fitzgerald, Peter Van Loo, Haig H Kazazian, Kathleen H Burns, PCAWG Structural Variant Working Group, Peter J Campbell, Jose M C Tubio, PCAWG Consortium (2018). Pan-Cancer Analysis of Whole Genomes Reveals Driver Rearrangements Promoted by LINE-1 Retrotransposition in Human Tumours. BioRxiv 179705. Cold Spring Harbor Laboratory https://doi.org/10.1038/s41588-019-0562-0.

Francesco Maura, Niccolo Bolli, Kevin J Dawson, Nicos Angelopoulos, Stephane Minvielle, Inigo Martincorena, Thomas J Mitchell, Anthony Fullam, Santiago Gonzalez, Dominik Glodzik, Raphael Szalat, Mehmet Kemal Samur, Mariateresa Fulciniti, Yu-Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth C Anderson, David C Wedge, Moritz Gerstung, Herve Avet-Loiseau, Nikhil Munshi, Peter J Campbell (2017). The Genomic Landscape of Multiple Myeloma Complex Structural Variations. Blood, 130 330. Elsevier https://doi.org/10.1182/blood.V130.Suppl_1.330.330.

Jacob Grinfeld, Jyoti Nangalia, E Joanna Baxter, Anna L Godfrey, Paola Guglielmelli, Rob Cantrill, David C Wedge, Nicos Angelopoulos, Gunes Gundem, Charlie Massie, Elli Papaemmanuil, Cathy MacLean, Julia Cook, Francesca L Nice, Christen Lykkegaard Andersen, Hans Carl Hasselbalch, Mary Frances McMullin, Alessandro M Vannucchi, Claire N Harrison, Moritz Gerstung, Anthony R Green (2017). 635 - Personalized Prognostic Predictions for Patients with Myeloproliferative Neoplasms through Integration of Comprehensive Genomic and Clinical Information. Blood, 130 491. Elsevier https://doi.org/10.1182/blood.V130.Suppl_1.491.491.

Jiqiu Cheng, Jonas Demeulemeester, David C Wedge, Hans Kristian M Vollan, Jason J Pitt, Hege G Russnes, Bina P Pandey, Gro Nilsen, Silje Nord, Graham R Bignell, Kevin P White, Anne-Lise Borresen-Dale, Peter J Campbell, Vessela Kristensen, Michael R Stratton, Ole Christian Lingjaerde, Yves Moreau, Peter Van Loo (2017). Pan-Cancer Analysis of Homozygous Deletions in Primary Tumours Uncovers Rare Tumour Suppressors. Nature communications, 8(1) 1–14. Nature Publishing Group https://doi.org/10.1038/s41467-017-01355-0.

Niedzica Camacho, Peter Van Loo, Sandra Edwards, Jonathan D Kay, Lucy Matthews, Kerstin Haase, Jeremy Clark, Nening Dennis, Sarah Thomas, Barbara Kremeyer, Jorge Zamora, Adam P Butler, Gunes Gundem, Sue Merson, Hayley Luxton, Steve Hawkins, Mohammed Ghori, Luke Marsden, Adam Lambert, Katalin Karaszi, Gill Pelvender, Charles E Massie, Zsofia Kote-Jarai, Keiran M Raine, David Jones, William Howat, Steven Hazell, Naomi Livni, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, David Nicol, Erik Mayer, Tim Dudderidge, Yongwei Yu, Hongwei Zhang, Nimish C Shah, Vincent Gnanapragasam, The CRUK-ICGC Prostate Group, William Isaacs, Tapio Visakorpi, Freddie C Hamdy, Dan M Berney, Clare Verrill, Anne Y Warren, David C Wedge, Andrew G Lynch, Christopher S Foster, Yong-Jie Lu, G Steven Bova, Hayley Whitaker, Ultan McDermott, David E Neal, Rosalind A Eeles, Colin S Cooper, Daniel S Brewer (2017). Appraising the Relevance of DNA Copy Number Loss and Gain in Prostate Cancer Using Whole Genome DNA Sequence Data. PLoS genetics, 13(9) e1007001. Public Library of Science San Francisco, CA USA https://doi.org/10.1371/journal.pgen.1007001.

Lucy R Yates, Stian Knappskog, David C Wedge, James HR Farmery, Santiago Gonzalez, Inigo Martincorena, Ludmil B Alexandrov, Peter Van Loo, Hans Kristian Haugland, Peer Kaare Lilleng, Gunes Gundem, Moritz Gerstung, Elli Papaemmanuil, Patrycja Gazinska, Shriram G Bhosle, David Jones, Keiran M Raine, Laura J Mudie, Calli Latimer, Elinor Sawyer, Christine Desmedt, Christos Sotiriou, Michael R Stratton, Anieta M Sieuwerts, Andrew G Lynch, John W M Martens, Andrea L Richardson, Andrew Tutt, Per E Lonning, Peter J Campbell (2017). Genomic Evolution of Breast Cancer Metastasis and Relapse. Cancer cell, 32(2) 169–184. Elsevier https://doi.org/10.1016/j.ccell.2017.07.005.

Stefan C Dentro, David C Wedge, Peter Van Loo (2017). Principles of Reconstructing the Subclonal Architecture of Cancers. Cold Spring Harbor perspectives in medicine, 7(8) a026625. Cold Spring Harbor Laboratory Press https://doi.org/https://www.doi.org/10.1101/cshperspect.a026625.

Sam Behjati, Patrick S Tarpey, Kerstin Haase, Hongtao Ye, Matthew D Young, Ludmil B Alexandrov, Sarah J Farndon, Grace Collord, David C Wedge, Inigo Martincorena, Susanna L Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P Butler, Jon W Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R Stratton, Adrienne M Flanagan, Peter J Campbell (2017). Recurrent Mutation of IGF Signalling Genes and Distinct Patterns of Genomic Rearrangement in Osteosarcoma. Nature communications, 8(1) 1–8. Nature Publishing Group https://doi.org/10.1038/ncomms15936.

Young Seok Ju, Inigo Martincorena, Moritz Gerstung, Mia Petljak, Ludmil B Alexandrov, Raheleh Rahbari, David C Wedge, Helen R Davies, Manasa Ramakrishna, Anthony Fullam, Sancha Martin, Christopher Alder, Nikita Patel, Stephen J Gamble, Sarah O'Meara, Dilip D Giri, Torril Sauer, Sarah E Pinder, Colin A Purdie, Ake Borg, Henk Stunnenberg, Marc van de Vijver, Benita Kiat Tee Tan, Carlos Caldas, Andrew Tutt, Naoto t Ueno, Laura Van't Veer, John W M Martens, Christos Sotiriou, Stian Knappskog, Paul N Span, Sunil R Lakhani, Jorunn Erla Eyfjord, Anne-Lise Borresen-Dale, Andrea Richardson, Alastair M Thompson, Alain Viari, Matthew E Hurles, Serena Nik-Zainal, Peter J Campbell, Michael R Stratton (2017). Somatic Mutations Reveal Asymmetric Cellular Dynamics in the Early Human Embryo. Nature, 543(7647) 714–718. Nature Publishing Group https://doi.org/10.1038/nature21703.

Geoff Macintyre, Peter Van Loo, Niall M Corcoran, David C Wedge, Florian Markowetz, Christopher M Hovens (2017). How Subclonal Modeling Is Changing the Metastatic Paradigm. Clinical Cancer Research, 23(3) 630–635. AACR https://doi.org/10.1158/1078-0432.CCR-16-0234.

Eleanor Gregson, Sarah Killcoyne, David C Wedge, Matthew Eldridge, Ahmad Miremadi, Katerina Jenkins, Rachel de la Rue, Lawrence Bower, Rebecca C Fitzgerald (2017). 445 - Shallow Whole Genome Sequencing Can Detect Copy Number Changes in FFPE Material in the Progression of Barrett's Esophagus. Gastroenterology, 5(152) S106. https://doi.org/http://dx.doi.org/10.1016%2FS0016-5085(17)30694-7.

Jonas Demeulemeester, Parveen Kumar, Elen K Moller, Silje Nord, David C Wedge, April Peterson, Randi R Mathiesen, Renathe Fjelldal, Masoud Zamani Esteki, Koen Theunis, Elia Fernandez Gallardo, Jason A Grundstad, Elin Borgen, Lars O Baumbusch, Anne-Lise Borresen-Dale, Kevin P White, Vessela Kristensen, Peter Van Loo, Thierry Voet, Bjorn Naume (2016). Tracing the Origin of Disseminated Tumor Cells in Breast Cancer Using Single-Cell Sequencing. Genome biology, 17(1) 1–15. Springer https://doi.org/10.1186/s13059-016-1109-7.

Keiran M Raine, Peter Van Loo, David C Wedge, David Jones, Andrew Menzies, Adam P Butler, Jon W Teague, Patrick Tarpey, Serena Nik-Zainal, Peter J Campbell (2016). ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data. Current protocols in bioinformatics, 56(1) 15–9. Wiley Online Library https://doi.org/10.1002/cpbi.17.

Raphael Szalat, Niccolo Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Florence Magrangeas, Philippe Moreau, Anthony Fullam, Mehmet K Samur, Patrick Tarpey, Nicholas Anthony DaSilva, Helen Davies, Inigo Martincorena, Kevin J Dawson, Jose Tubio, Jorge Zamora, Yu-Tzu Tai, Kenneth C Anderson, David C Wedge, Herve Avet-Loiseau, Peter J Campbell, Nikhil C Munshi (2016). The Complex Landscape of Rearrangements in Smoldering and Symptomatic Multiple Myeloma Revealed By Whole-Genome Sequencing. Blood, The Journal of the American Society of Hematology https://doi.org/10.1182/blood.V128.22.236.236.

Francesco Maura, Niccolo Bolli, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Mehmet Kemal Samur, Patrick Tarpey, Helen Davies, Kevin J Dawson, Serena Nik-Zainal, Moritz Gerstung, Jorge Zamora, Yu-Tsu Tai, Cristiana Carniti, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, David C Wedge, Herve Avet-Loiseau, Peter J Campbell, Nikhil Munshi (2016). Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma. Blood, 128(22) 116. Elsevier https://doi.org/10.1182/blood.V128.22.116.116.

Niccolo Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Mehmet Kemal Samur, Patrick Tarpey, Helen Davies, Inigo Martincorena, Kevin J Dawson, Thomas Mitchell, Jorge Zamora, Cristiana Carniti, Yu-Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth C Anderson, David C Wedge, Herve Avet-Loiseau, Peter J Campbell, Nikhil Munshi (2016). 651 - Whole Genome Sequencing of Unique Paired Smm-Mgus Progressing to Mm Samples Reveals a Genomic Landscape with Diverse Evolutionary Pattern. Blood, The Journal of the American Society of Hematology https://doi.org/10.1182/blood.V128.22.2088.2088.

Marios Dimitriou, Petter S Woll, Teresa Mortera-Blanco, Mohsen Karimi, David C Wedge, Helen Doolittle, Iyadh Douagi, Elli Papaemmanuil, Sten Eirik W Jacobsen, Eva Hellstrom-Lindberg (2016). Perturbed Hematopoietic Stem and Progenitor Cell Hierarchy in Myelodysplastic Syndromes Patients with Monosomy 7 as the Sole Cytogenetic Abnormality. Oncotarget, 7(45) 72685. Impact Journals, LLC https://doi.org/https://www.doi.org/10.18632/oncotarget.12234.

Sam Behjati, Gunes Gundem, David C Wedge, Nicola D Roberts, Patrick S Tarpey, Susanna L Cooke, Peter Van Loo, Ludmil B Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M Raine, Lucy A Stebbings, Andrew Menzies, David Jones, Rebecca Shepherd, Adam P Butler, Jon W Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G Steven Bova, Andrea L Richardson, Adrienne M Flanagan, Michael R Stratton, Peter J Campbell (2016). Mutational Signatures of Ionizing Radiation in Second Malignancies. Nature communications, 7(1) 1–8. Nature Publishing Group https://doi.org/https://www.doi.org/10.1038/ncomms12605.

Vandana Sandhu, David C Wedge, Inger Marie Bowitz Lothe, Knut Jorgen Labori, Stefan C Dentro, Trond Buanes, Martina L Skrede, Astrid M Dalsgaard, Else Munthe, Ola Myklebost, Ole Christian Lingjaerde, Anne-Lise Borresen-Dale, Tone Ikdahl, Peter Van Loo, Silje Nord, Elin H Kure (2016). The Genomic Landscape of Pancreatic and Periampullary AdenocarcinomaCopy Number Aberrations in Periampullary Adenocarcinomas. Cancer Research, 76(17) 5092–5102. AACR https://doi.org/10.1158/0008-5472.CAN-16-0658.

Adam Shlien, Keiran M Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R Davies, Patrick S Tarpey, Peter Van Loo, David C Wedge, David R Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, ICGC Breast Cancer Working Group, Oslo Breast Cancer Research Consortium, Violetta Barbashina, Samuel AJR Aparicio, Torill Sauer, Oystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerod, Ake Borg, Gilles Thomas, Andrea L Richardson, Anne-Lise Borresen-Dale, Kornelia Polyak, Michael R Stratton, Peter J Campbell (2016). Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer. Cell reports, 16(7) 2032–2046. Elsevier https://doi.org/10.1016/j.celrep.2016.07.028.

Elen K Moller, Silje Nord, David C Wedge, Ole Christian Lingjaerde, Laxmi Silwal-Pandit, Hedda vdL Gythfeld, Hans Kristian M Vollan, Thomas Fleischer, Marit Krohn, Ellen Schlichting, Elin Borgen, Oystein Garred, Marit M Holmen, Erik Wist, Bjorn Naume, Peter Van Loo, Anne-Lise Borresen-Dale, Olav Engebraten, Vessela Kristensen (2016). Abstract LB-337: Systemic Shift in Genomic Aberrations in Breast Carcinomas during Neoadjuvant Chemotherapy in Combination with Bevacizumab. Cancer Research, 76(14) LB–337. AACR https://doi.org/10.1158/1538-7445.AM2016-LB-337.

David C Wedge, Paul Spellman Paul T, Peter Van Loo (2016). 361 - Genomic Evolution and Heterogeneity in 2,800 Cancers. European Journal of Cancer, 1(61) S73. https://doi.org/10.1016/S0959-8049(16)61255-8.

Andrea Strakova, Maire Ni Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo Domracheva, Karina F de Castro, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F Hafelin Manrique, Joaquim JGP Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Martincorena Inigo, Simon Martinez Castaneda, Mayra F Martinez-Lopez, Michael Meyer, Berna Nakanwagi, Andrigo Barboza De Nardi, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vitalaru, Anna P de Vos, Johan P de Vos, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, Mirjam G van der Wel, Sophie AE Widdowson, Elizabeth P Murchison (2016). Mitochondrial Genetic Diversity, Selection and Recombination in a Canine Transmissible Cancer. elife, 5 eLife Sciences Publications, Ltd https://doi.org/10.7554/eLife.14552.

Serena Nik-Zainal, Helen Davies, Johan Staaf, Manasa Ramakrishna, Dominik Glodzik, Xueqing Zou, Inigo Martincorena, Ludmil B Alexandrov, Sancha Martin, David C Wedge, Peter Van Loo, Young Seok Ju, Marcel Smid, Arie B Brinkman, Sandro Morganella, Miriam R Aure, Ole Christian Lingjaerde, Anita Langerod, Markus Ringner, Sung-Min Ahn, Sandrine Boyault, Jane E Brock, Annegien Broeks, Adam P Butler, Christine Desmedt, Luc Dirix, Serge Dronov, Aquila Fatima, John A Foekens, Moritz Gerstung, Gerrit K J Hooijer, Se Jin Jang, David R Jones, Hyung-Yong Kim, Tari A King, Savitri Krishnamurthy, Hee Jin Lee, Jeong-Yeon Lee, Yilong Li, Stuart McLaren, Andrew Menzies, Ville Mustonen, Sarah O'Meara, Iris Pauporte, Xavier Pivot, Colin A Purdie, Keiran M Raine, Kamna Ramakrishnan, F German Rodriguez-Gonzalez, Gilles Romieu, Anieta M Sieuwerts, Peter T Simpson, Rebecca Shepherd, Lucy A Stebbings, Olafur A Stefansson, Jon W Teague, Stefania Tommasi, Isabelle Treilleux, Gert G Van Den Eynden, Peter Vermeulen, Anne Vincent-Salomon, Lucy R Yates, Carlos Caldas, Laura Van't Veer, Andrew Tutt, Stian Knappskog, Benita Kiat Tee Tan, Jos Jonkers, Ake Borg, Naoto t Ueno, Christos Sotiriou, Alain Viari, P Andrew Futreal, Peter J Campbell, Paul N Span, Steven Van Laere, Sunil R Lakhani, Jorunn Erla Eyfjord, Alastair M Thompson, Ewan Birney, Hendrik G Stunnenberg, Marc van de Vijver, John W M Martens, Anne-Lise Borresen-Dale, Andrea L Richardson, Gu Kong, Gilles Thomas, Michael R Stratton (2016). Landscape of Somatic Mutations in 560 Breast Cancer Whole-Genome Sequences. Nature, 534(7605) 47–54. Nature Publishing Group https://doi.org/10.1038/nature17676.

Carolyn S Grove, Niccolo Bolli, Nicla Manes, Ignacio Varela, Mars Van't Veer, Anthony Bench, Hesham Eldaly, David C Wedge, Peter Van Loo, George S Vassiliou (2016). Rapid Parallel Acquisition of Somatic Mutations after NPM1 in Acute Myeloid Leukaemia Evolution. British Journal of Haematology, 176(5) Wiley https://doi.org/10.1111/bjh.13999.

Adam Shlien, Brittany B Campbell, Richard De Borja, Ludmil B Alexandrov, Daniele Merico, David C Wedge, Peter Van Loo, Patrick S Tarpey, Paul Coupland, Aaron Pollett, Tatiana Lipman, Abolfazl Heidari, Shriya Deshmukh, Moritz Gerstung, Diana M Merino, Manasa Ramakrishna, Marc Remke, Roland Arnold, Gagan B Panigrahi, Samina Afzal, Valerie Larouche, Harriet Druker, Jordan Lerner-Ellis, Matthew Mistry, Rina Dvir, Ronald Grant, Ronit Elhasid, Roula Farah, Glenn P Taylor, Paul C Nathan, Sarah Alexander, Shay Ben-Shachar, Nada Jabado, Steven Gallinger, Shlomi Constantini, Peter Dirks, Annie Huang, Stephen W Scherer, Richard G Grundy, Carol Durno, Melyssa Aronson, M Stephen Meyn, Zachary F Pursell, Christopher E Pearson, David Malkin, P Andrew Futreal, Cynthia Hawkins, Eric Bouffet, Michael D Taylor, Peter J Campbell, Uri Tabori (2015). Abstract B09: DNA Polymerase Mutations Trigger Rapid Onset of Ultra-Hypermutant Malignant Brain Tumors in Children with Biallelic Mismatch Repair Deficiency. Cancer Research, 75(23) B09–B09. AACR https://doi.org/10.1158/1538-7445.BRAIN15-B09.

Ludmil B Alexandrov, Philip H Jones, David C Wedge, Julian E Sale, Peter J Campbell, Serena Nik-Zainal, Michael R Stratton (2015). Clock-like Mutational Processes in Human Somatic Cells. Nature genetics, 47(12) 1402–1407. Nature Publishing Group https://doi.org/10.1038/ng.3441.

Jyoti Nangalia, Francesca L Nice, David C Wedge, Anna L Godfrey, Jacob Grinfeld, Clare Thakker, Charlie E Massie, Joanna Baxter, David Sewell, Yvonne Silber, Peter J Campbell, Anthony R Green (2015). DNMT3A Mutations Occur Early or Late in Patients with Myeloproliferative Neoplasms and Mutation Order Influences Phenotype. Haematologica, 100(11) e438. Ferrata Storti Foundation https://doi.org/10.3324%2Fhaematol.2015.129510.

Lucy R Yates, David C Wedge, elax LB Alexandrov, Christine Desmedt, Stian Knappskog, Andrea L Richardson, Christos Sotiriou, Anieta M Sieuwerts, Andrew M Tutt, Michael Stratton, others (2015). 1818 - Evolution from Primary Breast Cancer to Relapse and Metastasis.. European Journal of Cancer https://doi.org/10.1016/S0959-8049(15)30037-X.

Heini ML Kallio, Matti Annala, Kati Kivinummi, Gunilla Hognas, Gunes Gundem, David C Wedge, Peter Van Loo, Holger Heyn, Michael R Emmert-Buck, William B Isaacs, Manel Esteller, Ultan McDermott, Matti Nykter, Tapio Visakorpi, G Steven Bova (2015). Clonal Evolution of a Lethal Prostate Cancer: Integrated Whole Genome Analysis Case Study. Cancer Research, 75(15) 3883–3883. AACR https://doi.org/10.1158/1538-7445.AM2015-3883.

Elen Moller, Parveen Kumar, Silje Nord, David C Wedge, Peter Van Loo, April Peterson, Randi R Mathiesen, Renathe Fjelldal, Masoud Z Esteki, Jason A Grundstad, Elin Borgen, Lars O Baumbusch, Anne-Lise Borresen-Dale, Kevin P White, Thierry Voet, Bjorn Naume, Vessela Kristensen (2015). Abstract LB-051: Tumor Heterogeneity and Dissemination in Breast Cancer: Deep Sequencing of Single Disseminated Cells from Bone Marrow Compared to Primary Tumor and Lymph Node Metastases. Cancer Research, 75(15) American Association for Cancer Research https://doi.org/10.1158/1538-7445.AM2015-LB-051.

Lucy R Yates, Moritz Gerstung, Stian Knappskog, Christine Desmedt, Gunes Gundem, Peter Van Loo, Turid Aas, Ludmil B Alexandrov, Denis Larsimont, Helen Davies, Yilong Li, Young Seok Ju, Manasa Ramakrishna, Hans Kristian Haugland, Peer K Lilleng, Serena Nik-Zainal, Stuart McLaren, Adam P Butler, Sancha Martin, Dominik Glodzik, Andrew Menzies, Keiran M Raine, Jonathan Hinton, David Jones, Laura J Mudie, Bing Jiang, Delphine Vincent, April Greene-Colozzi, Pierre-Yves Adnet, Aquila Fatima, Marion Maetens, Michail Ignatiadis, Michael R Stratton, Christos Sotiriou, Andrea L Richardson, Per E Lonning, David C Wedge, Peter J Campbell (2015). Subclonal Diversification of Primary Breast Cancer Revealed by Multiregion Sequencing. Nature medicine, 21(7) 751–759. Nature Publishing Group https://doi.org/10.1038/nm.3886.

Ayesha Noorani, David C Wedge, Pierre Lao-Sirieix, Jamie Weaver, Nicola Grehan, Irene Debiram, David Gilligan, Andrew Hindmarsh, Martin Goddard, Richard H Hardwick, Rebecca C Fitzgerald (2015). PTU-128 Novel Insights into Metastatic Spread of Oesophageal Adenocarcinoma from Whole Genome Sequencing Data. BMJ Publishing Group.

Inigo Martincorena, Amit Roshan, Moritz Gerstung, Peter Ellis, Peter Van Loo, Stuart McLaren, David C Wedge, Anthony Fullam, Ludmil B Alexandrov, Jose M Tubio, Lucy A Stebbings, Andrew Menzies, Sara Widaa, Michael R Stratton, Jones, Peter J Campbell (2015). High Burden and Pervasive Positive Selection of Somatic Mutations in Normal Human Skin. Science, 348(6237) 880–886. American Association for the Advancement of Science https://doi.org/10.1126/science.aaa6806.

Stian Knappskog, Elisabet O Berge, Ranjan Chrisanthar, Stephanie Geisler, Vidar Staalesen, Beryl Leirvaag, Synnove Yndestad, Elise de Faveri, Bard O Karlsen, David C Wedge, Lars A Akslen, Peer K Lilleng, Erik Lokkevik, Steinar Lundgren, Bjorn Ostenstad, Terje Risberg, Ingvild Mjaaland, Turid Aas, Per E Lonning (2015). Concomitant Inactivation of the P53-and pRB-Functional Pathways Predicts Resistance to DNA Damaging Drugs in Breast Cancer in Vivo. Molecular oncology, 9(8) 1553–1564. Elsevier https://doi.org/10.1016/j.molonc.2015.04.008.

Matthew KH Hong, Geoff Macintyre, David C Wedge, Peter Van Loo, Keval Patel, Sebastian Lunke, Ludmil B Alexandrov, Clare Sloggett, Marek Cmero, Francesco Marass, Dana Tsui, Steafano Mangiola, Andrew Lonie, Haroon Naeem, Nikhil Sapre, Pramit Phal, Natalie Kurganovs, Xiaowen Chin, Michael Kerger, Anne Y Warren, David E Neal, Vincent Gnanapragasam, Nitzan Rosenfeld, John S Pedersen, Andrew Ryan, Izhak Haviv, Anthony Costello, Niall M Corcoran, Christopher M Hovens (2015). Tracking the Origins and Drivers of Subclonal Metastatic Expansion in Prostate Cancer. Nature communications, 6(1) 1–12. Nature Publishing Group https://doi.org/10.1038/nature09744.

Gunes Gundem, Peter Van Loo, Barbara Kremeyer, Ludmil B Alexandrov, Jose Tubio, Elli Papaemmanuil, Daniel S Brewer, Heini ML Kallio, Gunilla Hognas, Matti Annala, Kati Kivinummi, Victoria Goody, Calli Latimer, Sarah O'Meara, Kevin J Dawson, William B Isaacs, Michael R Emmert-Buck, Matti Nykter, Christopher S Foster, Zsofia Kote-Jarai, Douglas F Easton, Hayley Whitaker, The ICGC Prostate UK Group, David E Neal, Colin S Cooper, Rosalind A Eeles, Tapio Visakorpi, Peter J Campbell, Ultan McDermott, David C Wedge, G Steven Bova (2015). The Evolutionary History of Lethal Metastatic Prostate Cancer. Nature, 520(7547) 353–357. Nature Publishing Group https://doi.org/10.1038/nature14347.

Thomas J Mitchell, Kevin J Dawson, Peter Van Loo, David C Wedge (2015). 168 Evolution of Copy Number Aberrations with Time and Gleason Grade in Localised Prostate Cancer. European Urology Supplements, 2(14) e168–e168a. https://doi.org/10.1016/S1569-9056(15)60170-1.

Colin S Cooper, Rosalind Eeles, David C Wedge, Peter Van Loo, Gunes Gundem, Ludmil B Alexandrov, Barbara Kremeyer, Adam Butler, Andrew G Lynch, Niedzica Camacho, Charles E Massie, Jonathan Kay, Hayley Luxton, Sandra Edwards, Zsofia Kote-Jarai, Nening Dennis, Sue Merson, Daniel Leongamornlert, Jorge Zamora, Cathy Corbishley, Sarah Thomas, Serena Nik-Zainal, Manasa Ramakrishna, Sarah O'Meara, Lucy Matthews, Jeremy Clark, Rachel Hurst, Richard F Mithen, Robert G Bristow, Paul C Boutros, Michael Fraser, Susanna L Cooke, Keiran M Raine, David Jones, Andrew Menzies, Lucy A Stebbings, Jon Hinton, Jon W Teague, Stuart McLaren, Laura J Mudie, Claire Hardy, Elizabeth Anderson, Olivia R Joseph, Victoria Goody, Ben Robinson, Mark Maddison, Stephen J Gamble, Christopher D Greenman, Dan M Berney, Steven Hazell, Naomi Livni, The ICGC Prostate Group, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, Christopher Woodhouse, David Nicol, Erik Mayer, Tim Dudderidge, Nimish C Shah, Vincent Gnanapragasam, Thierry Voet, Peter J Campbell, P Andrew Futreal, Douglas F Easton, Anne Y Warren, Christopher S Foster, Michael R Stratton, Hayley Whitaker, Ultan McDermott, Daniel S Brewer, David E Neal (2015). Analysis of the Genetic Phylogeny of Multifocal Prostate Cancer Identifies Multiple Independent Clonal Expansions in Neoplastic and Morphologically Normal Prostate Tissue. Nature genetics, 47(4) 367–372. Nature Publishing Group https://doi.org/10.1038/ng.3221.

Dagmar Drogan, Warwick B Dunn, Wanchang Lin, Brian Buijsse, Matthias B Schulze, Claudia Langenberg, Marie Brown, Anna Floegel, Stefan Dietrich, Olov Rolandsson, David C Wedge, Royston Goodacre, Nita G Forouhi, Stephen J Sharp, Joachim Spranger, Nick J Wareham, Heiner Boeing (2015). Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study. Clinical chemistry, 61(3) 487–497. Oxford University Press https://doi.org/10.1373/clinchem.2014.228965.

Christopher Hovens, Matthew Hong, Geoff Macintyre, David C Wedge, Peter Van Loo, Sebastian Lunke, Ludmil B Alexandrov, Clare Slogget, Marek Cmero, Stefano Mangiola, Andrew Lonie, Haroon Naeem, Nikhil Sapre, Pramit Phal, Michael Kerger, John S Pedersen, Andrew Ryan, Izhak Haviv, Anthony Costello, Niall M Corcoran (2015). Tracking Clonal Diversity in Metastatic Prostate Cancer Progression.. Journal of Clinical Oncology, 33(7 Supplementary) https://doi.org/doi.org/10.1200/jco.2015.33.7_suppl.193.

Christina A Ortmann, David G Kent, Jyoti Nangalia, Yvonne Silber, David C Wedge, Jacob Grinfeld, E Joanna Baxter, Charles E Massie, Elli Papaemmanuil, Suraj Menon, Anna L Godfrey, Danai Dimitropolou (2015). Effect of Mutation Order on Myeloproliferative Neoplasms. New England Journal of Medicine, 372(7) 601–612. Mass Medical Soc https://doi.org/https://www.doi.org/10.1056/NEJMoa1412098.

Adam Shlien, Brittany B Campbell, Richard De Borja, Ludmil B Alexandrov, Daniele Merico, David C Wedge, Peter Van Loo, Patrick S Tarpey, Paul Coupland, Sam Behjati, Aaron Pollett, Tatiana Lipman, Abolfazl Heidari, Shriya Deshmukh, Na'ama Avitzur, Bettina Meier, Moritz Gerstung, Ye Hong, Diana M Merino, Manasa Ramakrishna, Marc Remke, Roland Arnold, Gagan B Panigrahi, Neha P Thakkar, Karl P Hodel, Erin E Henninger, A Yasemin Goksenin, Doua Bakry, George S Charames, Harriet Druker, Jordan Lerner-Ellis, Matthew Mistry, Rina Dvir, Ronald Grant, Ronit Elhasid, Roula Farah, Glenn P Taylor, Paul C Nathan, Sarah Alexander, Shay Ben-Shachar, Simon C Ling, Steven Gallinger, Shlomi Constantini, Peter Dirks, Annie Huang, Stephen W Scherer, Richard G Grundy, Carol Durno, Melyssa Aronson, Anton Gartner, M Stephen Meyn, Michael D Taylor, Zachary F Pursell, Christopher E Pearson, David Malkin, P Andrew Futreal, Michael R Stratton, Eric Bouffet, Cynthia Hawkins, Peter J Campbell, Uri Tabori, The Biallelic Mismatch Repair Deficiency Consortium (2015). Combined Hereditary and Somatic Mutations of Replication Error Repair Genes Result in Rapid Onset of Ultra-Hypermutated Cancers. Nature genetics, 47(3) 257–262. Nature Publishing Group https://doi.org/10.1038/ng.3202.

Nadege Presneau, Daniel Baumhoer, Sam Behjati, Nischalan Pillay, Patrick Tarpey, Peter J Campbell, Gernot Jundt, Rifat Hamoudi, David C Wedge, Peter Van Loo, A Bassim Hassan, Bhavisha Khatri, Hongtao Ye, Roberto Tirabosco, M Fernanda Amary, Adrienne M Flanagan (2015). Diagnostic Value of H3F3A Mutations in Giant Cell Tumour of Bone Compared to Osteoclast-Rich Mimics. The Journal of Pathology: Clinical Research, 1(2) 113–123. Wiley Online Library https://doi.org/10.1002/cjp2.13.

Naim U Rashid, Adam S Sperling, Niccolo Bolli, David C Wedge, Peter Van Loo, Yu-Tzu Tai, Masood A Shammas, Mariateresa Fulciniti, Mehmet K Samur, Paul G Richardson, Florence Magrangeas, Stephane Minvielle, P Andrew Futreal, Kenneth C Anderson, Herve Avet-Loiseau, Peter J Campbell, Giovanni Parmigiani, Nikhil C Munshi (2014). Differential and Limited Expression of Mutant Alleles in Multiple Myeloma. Blood, The Journal of the American Society of Hematology, 124(20) 3110–3117. American Society of Hematology Washington, DC https://doi.org/10.1182/blood-2014-04-569327.

Elza C De Bruin, Nicholas McGranahan, Richard Mitter, Max Salm, David C Wedge, Lucy Yates, Mariam Jamal-Hanjani, Seema Shafi, Nirupa Murugaesu, Andrew J Rowan, Eva Gronroos, Madiha A Muhammad, Stuart Horswell, Marco Gerlinger, Ignacio Varela, David Jones, John Marshall, Thierry Voet, Peter Van Loo, Doris M Rassl, Robert C Rintoul, Sam M Janes, Siow-Ming Lee, Martin Forster, Tanya Ahmad, David Lawrence, Mary Falzon, Arrigo Capitanio, Timothy T Harkins, Clarence C Lee, Tom Warren, Enock Teefe, Shann-Ching Chen, Sharmin Begum, Adam Rabinowitz, Benjamin Phillimore, Bradley Spencer-Dene, Gordon Stamp, Zoltan Szallasi, Nik Matthews, Aengus Stewart, Peter J Campbell, Charles Swanton (2014). Spatial and Temporal Diversity in Genomic Instability Processes Defines Lung Cancer Evolution. Science, 346(6206) 251–256. American Association for the Advancement of Science https://doi.org/10.1126/science.1253462.

Jianjun Zhang, Junya Fujimoto, Jianhua Zhang, David C Wedge, Xingzhi Song, Jiexin Zhang, Sahil Seth, Chi-Wan Chow, Yu Cao, Curtis Gumbs, Kathryn A Gold, Neda Kalhor, Latasha Little, Harshad Mahadeshwar, Cesar Moran, Alexei Protopopov, Huandong Sun, Jiabin Tang, Xifeng Wu, Yuanqing Ye, William N William, J Jack Lee, John V Heymach, Waun Ki Hong, Stephen Swisher, Ignacio I Wistuba, P Andrew Futreal (2014). Intratumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multiregion Sequencing. Science, 346(6206) 256–259. American Association for the Advancement of Science https://doi.org/10.1126/science.1256930.

Piotr S Gromski, Elon Correa, Andrew A Vaughan, David C Wedge, Michael L Turner, Royston Goodacre (2014). A Comparison of Different Chemometrics Approaches for the Robust Classification of Electronic Nose Data. Analytical and bioanalytical chemistry, 406(29) 7581–7590. Springer https://doi.org/10.1007/s00216-014-8216-7.

Elza D Bruin, Nicholas McGranahan, Lucy Yates, Mariam Jamal-Hanjani, Max Salm, Richard Mitter, Seema Shafi, Nirupa Murugaesu, Andrew Rowan, Marco Gerlinger, David C Wedge, Stuart Horswell, Ignacio Varela, Warren Tom, Chaitali Parikh, Timothy Harkins, Clarence Lee, Nik Matthews, Aengus Stewart, Peter J Campbell, Charles Swanton (2014). Intratumor Heterogeneity in Non-Small Cell Lung Cancer Inferred by Multi-Region Exome Sequencing. Cancer Research. , 74 983–983. AACR https://doi.org/10.1158/1538-7445.AM2014-983.

Andrea Gobbi, Francesco Iorio, Kevin J Dawson, David C Wedge, David Tamborero, Ludmil B Alexandrov, Nuria Lopez-Bigas, Mathew J Garnett, Giuseppe Jurman, Julio Saez-Rodriguez (2014). Fast Randomization of Large Genomic Datasets While Preserving Alteration Counts. Bioinformatics, 30(17) i617–i623. Oxford University Press https://doi.org/10.1093/bioinformatics/btu474.

Mariam Jamal-Hanjani, G Wilson, Elza C De Bruin, Nicholas McGranahan, R Mitter, M Salm, David C Wedge, A Rowan, Peter J Campbell, Charles Swanton (2014). Evolution of the Genomic Landscape in Non-Small Cell Lung Cancer. Annals of Oncology, 25 v1. Elsevier https://doi.org/10.1093/annonc/mdu438.44.

Jose MC Tubio, Yilong Li, Young Seok Ju, Inigo Martincorena, Susanna L Cooke, Marta Tojo, Gunes Gundem, Christodoulos P Pipinikas, Jorge Zamora, Keiran M Raine, Andrew Menzies, Pablo Roman-Garcia, Anthony Fullam, Moritz Gerstung, Adam Shlien, Patrick S Tarpey, Elli Papaemmanuil, Stian Knappskog, Peter Van Loo, Manasa Ramakrishna, Helen R Davies, John Marshall, David C Wedge, Jon W Teague, Adam P Butler, Serena Nik-Zainal, Ludmil B Alexandrov, Sam Behjati, Lucy R Yates, Niccolo Bolli, Laura J Mudie, Claire Hardy, Sancha Martin, Stuart McLaren, Sarah O'Meara, Elizabeth Anderson, Mark Maddison, Stephen J Gamble, ICGC Breast Cancer Group, ICGC Bone Cancer Group, ICGC Prostate Cancer Group, Christopher Foster, Anne Y Warren, Hayley Whitaker, Daniel S Brewer, Rosalind A Eeles, Colin S Cooper, David E Neal, Andrew G Lynch, Tapio Visakorpi, William B Isaacs, Laura Van't Veer, Carlos Caldas, Christine Desmedt, Christos Sotiriou, Samuel A Aparicio, John A Foekens, Jorunn Erla Eyfjord, Sunil R Lakhani, Gilles Thomas, Ola Myklebost, Paul N Span, Anne-Lise Borresen-Dale, Andrea L Richardson, Marc van de Vijver, Anne Vincent-Salomon, Gert G Van Den Eynden, Adrienne M Flanagan, P Andrew Futreal, Sam M Janes, G Steven Bova, Michael R Stratton, Ultan McDermott, Peter J Campbell (2014). Extensive Transduction of Nonrepetitive DNA Mediated by L1 Retrotransposition in Cancer Genomes. Science, 345(6196) 1251343. American Association for the Advancement of Science https://doi.org/10.1126/science.1251343.

Sam Behjati, Meritxell Huch, Ruben van Boxtel, Wouter Karthaus, David C Wedge, Asif U Tamuri, Inigo Martincorena, Mia Petljak, Ludmil B Alexandrov, Gunes Gundem, Patrick S Tarpey, Sophie Roerink, Joyce Blokker, Mark Maddison, Laura J Mudie, Ben Robinson, Serena Nik-zainal, Serena, Peter J Campbell, Nick Goldman, Marc van de Wetering, Edwin Cuppen, Hans Clevers, Michael R Stratton (2014). Genome Sequencing of Normal Cells Reveals Developmental Lineages and Mutational Processes. Nature, 513(7518) 422–425. Nature Publishing Group https://doi.org/10.1038/nature13448.

Petter S Woll, Una Kjallquist, Onima Chowdhury, Helen Doolittle, David C Wedge, Supat Thongjuea, Rikard Erlandsson, Mtakai Ngara, Kristina Anderson, Qiaolin Deng, Adam J Mead, Laura Stenson, Alice Giustacchini, Sara Duarte, Eleni Giannoulatou, Stephen Taylor, Mohsen Karimi, Christian Scharenberg, Teresa Mortera-Blanco, Iain C Macaulay, Sally-Ann Clark, Ingunn Dybedal, Dag Josefsen, Pierre Fenaux, Peter Hokland, Mette S Holm, Mario Cazzola, Luca Malcovati, Sudhir Tauro, David Bowen, Jacqueline Boultwood, Andrea Pellagatti, John E Pimanda, Ashwin Unnikrishnan, Paresh Vyas, Gudrun Gohring, Brigitte Schlegelberger, Magnus Tobiasson, Gunnar Kvalheim, Stefan N Constantinescu, Claus Nerlov, Lars Nilsson, Peter J Campbell, Rickard Sandberg, Elli Papaemmanuil, Eva Hellstrom-Lindberg, Sten Linnarsson, Sten Eirik W Jacobsen (2014). Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells in Vivo. Cancer cell, 25(6) 794–808. Elsevier https://doi.org/10.1016/j.ccr.2014.03.036.

Lucy Rebecca Connolly, Stian Knappskog, Christine Desmedt, David C Wedge, Peter Van Loo, Moritz Gerstung, Aquila Fatima, Andrea Richardson, Per Eystein Lonning, Christos Sotiriou, Michael R Stratton, Peter J Campbell (2014). Genomic Heterogeneity in Primary Breast Cancer: Clinical Implications.. Journal of Clinical Oncology. , 32 American Society of Clinical Oncology https://doi.org/doi.org/10.1200/jco.2014.32.15_suppl.11004.

Stian Knappskog, Liv B Gansmo, Khadizha Dibirova, Andres Metspalu, Cezary Cybulski, Paolo Peterlongo, Lauri Aaltonen, Lars Vatten, Pal Romundstad, Kristian Hveem, Peter Devilee, Gareth D Evans, Dongxin Lin, Guy Van Camp, Vangelis G Manolopoulos, Ana Osorio, Lili Milani, Tayfun Ozcelik, Pierre Zalloua, Francis Mouzaya, Elena Bliznetz, Elena Balanovska, Elvira Pocheshkova, Vaidutis Kucinskas, Lubov Atramentova, Pagbajabyn Nymadawa, Konstantin Titov, Maria Lavryashina, Yuldash Yusupov, Natalia Bogdanova, Sergey Koshel, Jorge Zamora, David C Wedge, Deborah Charlesworth, Thilo Dork, Oleg Balanovsky, Lonning (2014). Population Distribution and Ancestry of the Cancer Protective MDM2 SNP285 (Rs117039649). Oncotarget, 5(18) 8223. Impact Journals, LLC https://doi.org/10.18632%2Foncotarget.1910.

Serena Nik-Zainal, David C Wedge, Ludmil B Alexandrov, Mia Petljak, Adam P Butler, Niccolo Bolli, Helen R Davies, Stian Knappskog, Sancha Martin, Elli Papaemmanuil, Manasa Ramakrishna, Adam Shlien, Ingrid Simonic, Yali Xue, Chris Tyler-Smith, Peter J Campbell, Michael R Stratton (2014). Association of a Germline Copy Number Polymorphism of APOBEC3A and APOBEC3B with Burden of Putative APOBEC-Dependent Mutations in Breast Cancer. Nature genetics, 46(5) 487–491. Nature Publishing Group https://doi.org/10.1038/ng.2955.

Matthew Hong, Geoff Macintyre, Clare Sloggett, Marek Cmero, Andrew Lonie, Haroon Naeem, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Nikhil Sapre, Pramit Phal, Xiaowen Chin, Michael Kerger, John Pedersen, Andrew Ryan, Anthony Costello, Ultan McDermott, Niall M Corcoran, Christopher M Hovens (2014). MP49-06 GENOMIC ANALYSIS OF MULTIPLE PROSTATE CANCER METASTASES HIGHLIGHTS METASTASIS FROM LOW-GRADE CANCER FOCI AND DYNAMIC ADAPTATIONS TO THERAPY. The Journal of Urology, 191(4S) e504–e504. Wolters Kluwer Philadelphia, PA https://doi.org/10.1016/j.juro.2014.02.1107.

Matthew Hong, Geoff Macintyre, Clare Sloggett, Marek Cmero, Andrew Lonie, Haroon Naeem, David C Wedge, Peter Van Loo, Ludmil Alexandrov, Nikhil Sapre, Pramit Phal, Xiaowen Chin, Michael Kerger, John Pedersen, Andrew Ryan, Anthony Costello, Ultan McDermott, Niall M Corcoran, Christopher M Hovens (2014). MP49-01 SUBCLONAL ORIGIN OF PROSTATE CANCER METASTASIS WITH MUTATOR PHENOTYPE FROM A NOVEL MSH2 GENE FUSION. The Journal of Urology, 191(4S) e502–e502. Wolters Kluwer Philadelphia, PA https://doi.org/10.1016/j.juro.2014.02.1102.

Sam Behjati, Patrick S Tarpey, Helen Sheldon, Inigo Martincorena, Peter Van Loo, Gunes Gundem, David C Wedge, Manasa Ramakrishna, Susanna L Cooke, Nischalan Pillay, Hans Kristian M Vollan, Elli Papaemmanuil, Hans Koss, Tom D Bunney, Claire Hardy, Olivia R Joseph, Sancha Martin, Laura J Mudie, Adam P Butler, Jon W Teague, Meena Patil, Graham Steers, Yu Cao, Curtis Gumbs, Davis Ingram, Alexander J Lazar, Latasha Little, Harshad Mahadeshwar, Alexei Protopopov, Ghadah A Al Sannaa, Sahil Seth, Xingzhi Song, Jiabin Tang, Jianhua Zhang, Vinod Ravi, Keila E Torres, Bhavisha Khatri, Dina Halai, Ioannis Roxanis, Daniel Baumhoer, Roberto Tirabosco, M Fernanda Amary, Chris Boshoff, Ultan McDermott, Matilda Katan, Michael R Stratton, P Andrew Futreal, Adrienne M Flanagan, Adrian Harris, Peter J Campbell (2014). Recurrent PTPRB and PLCG1 Mutations in Angiosarcoma. Nature genetics, 46(4) 376–379. Nature Publishing Group https://doi.org/10.1038/ng.2921.

Elizabeth P Murchison, David C Wedge, Ludmil B Alexandrov, Beiyuan Fu, Inigo Martincorena, Zemin Ning, Jose MC Tubio, Emma I Werner, Jan Allen, Andrigo Barboza De Nardi, Edward M Donelan, Gabriele Marino, Ariberto Fassati, Peter J Campbell, Fengtang Yang, Austin Burt, Robin A Weiss, Michael R Stratton (2014). Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage. Science, 343(6169) 437–440. American Association for the Advancement of Science https://doi.org/10.1126/science.1247167.

Niccolo Bolli, Herve Avet-Loiseau, David C Wedge, Peter Van Loo, Ludmil B Alexandrov, Inigo Martincorena, Kevin J Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan Hinton, Yilong Li, Jose M C Tubio, Stuart McLaren, Sarah O'Meara, Adam P Butler, Jon W Teague, Laura J Mudie, Elizabeth Anderson, Naim U Rashid, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Giovanni Parmigiani, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, Thierry Facon, P Andrew Futreal, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi (2014). Heterogeneity of Genomic Evolution and Mutational Profiles in Multiple Myeloma. Nature communications, 5(1) 1–13. Nature Publishing Group https://doi.org/10.1038/ncomms3997.

Elli Papaemmanuil, Inmaculada Rapado, Yilong Li, Nicola E Potter, David C Wedge, Jose Tubio, Ludmil B Alexandrov, Peter Van Loo, Susanna L Cooke, John Marshall, Inigo Martincorena, Jonathan Hinton, Gunes Gundem, Frederik W van Delft, Serena Nik-Zainal, David R Jones, Manasa Ramakrishna, Ian Titley, Lucy A Stebbings, Catherine Leroy, Andrew Menzies, John Gamble, Ben Robinson, Laura J Mudie, Keiran M Raine, Sarah O'Meara, Jon W Teague, Adam P Butler, Giovanni Cazzaniga, Andrea Biondi, Jan Zuna, Helena Kempski, Markus Muschen, Anthony Ford, Michael R Stratton, Mel Greaves, Peter J Campbell (2014). RAG-Mediated Recombination Is the Predominant Driver of Oncogenic Rearrangement in ETV6-RUNX1 Acute Lymphoblastic Leukemia. Nature genetics, 46(2) 116–125. Nature Publishing Group https://doi.org/10.1038/ng.2874.

Jyoti Nangalia, Charles E Massie, E Joanna Baxter, Francesca L Nice, Gunes Gundem, David C Wedge, Edward Avezov, Juan Li, Karoline Kollmann, David G Kent, Athar Aziz, Anna L Godfrey, Jonathan Hinton, Inigo Martincorena, Peter Van Loo, Amy V Jones, Paola Guglielmelli, Patrick S Tarpey, Heather P Harding, John D Fitzpatrick, Calum T Goudie, Christina A Ortmann, Stephen J Loughran, Keiran M Raine, David R Jones, Adam P Butler, Jon W Teague, Sarah O'Meara, Stuart McLaren, Michele Bianchi, Yvonne Silber, Danai Dimitropolou, David Bloxham, Laura J Mudie, Mark Maddison, Ben Robinson, Clodagh Keohane, Cathy MacLean, Kate Hill, Kim H Orchard, Sudhir Tauro, Ming-Qing Du, Mel Greaves, David Bowen, Brian Huntly, Claire N Harrison, Nicholas C P Cross, David Ron, Alessandro M Vannucchi, Elli Papaemmanuil, Peter J Campbell, Anthony R Green (2013). Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2. New England Journal of Medicine, 369(25) 2391–2405. Mass Medical Soc https://doi.org/10.1056/NEJMoa1312542.

Jennifer Yen, Richard M White, David C Wedge, Peter Van Loo, Jeroen de Ridder, Amy Capper, Jennifer Richardson, David Jones, Keiran Raine, Ian R Watson, Chang-Jiun Wu, Jiqiu Cheng, Inigo Martincorena, Serena Nik-Zainal, Laura J Mudie, Yves Moreau, John Marshall, Manasa Ramakrishna, Patrick Tarpey, Adam Shlien, Ian Whitmore, Stephen J Gamble, Calli Latimer, Erin Langdon, Charles Kaufman, Mike Dovey, Alison Taylor, Andrew Menzies, Stuart McLaren, Sarah O'Meara, Adam P Butler, Jon W Teague, James Lister, Lynda Chin, Peter J Campbell, David J Adams, Leonard I Zon, E Elizabeth Patton, Derek L Stemple, P Andrew Futreal (2013). The Genetic Heterogeneity and Mutational Burden of Engineered Melanomas in Zebrafish Models. Genome biology, 14(10) 1–14. Springer https://doi.org/10.1186/gb-2013-14-10-r113.

Elli Papaemmanuil, Moritz Gerstung, Luca Malcovati, Sudhir Tauro, Gunes Gundem, Peter Van Loo, Chris J Yoon, Peter Ellis, David C Wedge, Andrea Pellagatti, Adam Shlien, Michael John Groves, Simon A Forbes, Keiran M Raine, Jonathan Hinton, Laura J Mudie, Stuart McLaren, Claire Hardy, Calli Latimer, Matteo G Della Porta, Sarah O'Meara, Ilaria Ambaglio, Anna Galli, Adam P Butler, Gunilla Walldin, Jon W Teague, Lynn Quek, Alex Sternberg, Carlo Gambacorti-Passerini, Nicholas C P Cross, Anthony R Green, Jacqueline Boultwood, Paresh Vyas, Eva Hellstrom-Lindberg, David Bowen, Mario Cazzola, Michael R Stratton, Peter J Campbell, Chronic Myeloid Disorders working group of the International Cancer Genome Consortium (2013). Clinical and Biological Implications of Driver Mutations in Myelodysplastic Syndromes. Blood, The Journal of the American Society of Hematology, 122(22) 3616–3627. American Society of Hematology Washington, DC https://doi.org/10.1182/blood-2013-08-518886.

Jyoti Nangalia, Charles Massie, E Joanna Baxter, Francesca L Nice, Gunes Gundem, David C Wedge, Edward Avezov, Juan Li, Karoline Kollmann, David G Kent, Athar Aziz, Anna L Godfrey, Jonathan Hinton, Inigo Martincorena, Peter Van Loo, Amy V Jones, Paola Guglielmelli, Patrick S Tarpey, Heather P Harding, John D Fitzpatrick, Calum T Goudie, Christina A Ortmann, Stephen J Loughran, Keiran M Raine, David Jones David R, Adam P Butler, Jon W Teague, Sarah O'Meara, Stuart McLaren, Michele Bianchi, Yvonne Silber, Danai Dimitropolou, David Bloxham, Laura J Mudie, Mark Maddison, Ben Robinson, Clodagh Keohane, Cathy MacLean, Kate Hill, Kim H Orchard, Sudhir Tauro, Ming-Qing Du, Mel Greaves, David Bowen, Brian Huntly, Claire N Harrison, Nicholas C P Cross, David Ron, Alessandro M Vannucchi, Elli Papaemmanuil, Peter J Campbell, Anthony R Green (2013). The Genomic Landscape of Myeloproliferative Neoplasms: Somatic Calr Mutations in the Majority of JAK2-Wildtype Patients. Blood, The Journal of the American Society of Hematology https://doi.org/10.1182/blood.V122.21.LBA-2.LBA-2.

Niccolo Bolli, Herve Avet-Loiseau, David Wedge, Peter Van Loo, Ludmil Alexandrov, Inigo Martincorena, Kevin Dawson, Francesco Iorio, Serena Nik-Zainal, Graham R Bignell, Jonathan Hinton, Jose Tubio, Stuart McLaren, Sarah O'Meara, Adam P Butler, Jon W Teague, Laura J Mudie, Yu-Tzu Tai, Masood A Shammas, Adam S Sperling, Mariateresa Fulciniti, Paul G Richardson, Florence Magrangeas, Stephane Minvielle, Philippe Moreau, Michel Attal, P Andrew Futreal, Thierry Facon, Kenneth C Anderson, Peter J Campbell, Nikhil C Munshi (2013). 651 - Whole Exome Sequencing Of Multiple Myeloma Reveals An Heterogeneous Clonal Architecture and Genomic Evolution. Blood, The Journal of the American Society of Hematology https://doi.org/10.1182/blood.V122.21.399.399.

Sam Behjati, Patrick S Tarpey, Nadege Presneau, Susanne Scheipl, Nischalan Pillay, Peter Van Loo, David C Wedge, Susanna L Cooke, Gunes Gundem, Helen Davies, Serena Nik-Zainal, Sancha Martin, Stuart McLaren, Victoria Goody, Ben Robinson, Adam P Butler, Jon W Teague, Dina Halai, Bhavisha Khatri, Ola Myklebost, Daniel Baumhoer, Gernot Jundt, Rifat Hamoudi, Roberto Tirabosco, M Fernanda Amary, P Andrew Futreal, Michael R Stratton, Peter J Campbell, Adrienne M Flanagan (2013). Distinct H3F3A and H3F3B Driver Mutations Define Chondroblastoma and Giant Cell Tumor of Bone. Nature genetics, 45(12) 1479–1482. Nature Publishing Group https://doi.org/10.1038/ng.2814.

Jiqiu Cheng, Hans Kristian M Vollan, David C Wedge, Anne-Lise Borresen-Dale, Campbell Campbell Peter J, Vessela Kristensen, Michael R Stratton, Ole Christian Lingjaerde, Yves Moreau, Peter Van Loo (2013). The Landscape of Tumor Suppressors across Human Cancers. EUROPEAN JOURNAL OF CANCER. , 49 S6–S6. ELSEVIER SCI LTD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB ….

Ludmil B Alexandrov, Serena Nik-Zainal, David C Wedge, Samuel AJR Aparicio, Sam Behjati, Andrew V Biankin, Graham R Bignell, Niccolo Bolli, Ake Borg, Anne-Lise Borresen-Dale, Sandrine Boyault, Brigit Burkhardt, Adam P Butler, Carlos Caldas, Helen R Davies, Christine Desmedt, Roland Eils, Jorunn Erla Eyfjord, John A Foekens, Mel Greaves, Fumie Hosoda, Barbara Hutter, Tomislav Ilicic, Sandrine Imbeaud, Marcin Imielinski, Natalie Jager, David T W Jones, David Jones, Stian Knappskog, Marcel Kool, Sunil R Lakhani, Carlos Lopez-Otin, Sancha Martin, Nikhil C Munshi, Hiromi Nakamura, Paul A Northcott, Marina Pajic, Elli Papaemmanuil, Angelo Paradiso, John V Pearson, Xose S Puente, Keiran M Raine, Manasa Ramakrishna, Andrea L Richardson, Julia Richter, Philip Rosenstiel, Matthias Schlesner, Ton N Schumacher, Paul N Span, Jon W Teague, Yasushi Totoki, Andrew N J Tutt, Rafael Valdes-Mas, Marit M van Buuren, Laura Van't Veer, Anne Vincent-Salomon, Nicola Waddell, Lucy R Yates, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Jessica Zucman-Rossi, P Andrew Futreal, Ultan McDermott, Peter Lichter, Matthew Meyerson, Sean M Grimmond, Reiner Siebert, Elias Campo, Tatsuhiro Shibata, Stefan M Pfister, Peter J Campbell, Michael R Stratton (2013). Signatures of Mutational Processes in Human Cancer. Nature, 500(7463) 415–421. Nature Publishing Group https://doi.org/10.1038/nature12477.

Philip J Stephens, Helen R Davies, Yoshitsugu Mitani, Peter Van Loo, Adam Shlien, Patrick S Tarpey, Elli Papaemmanuil, Angela Cheverton, Graham R Bignell, Adam P Butler, John Gamble, Stephen J Gamble, Claire Hardy, Jonathan Hinton, Mingming Jia, Alagu Jayakumar, David R Jones, Calli Latimer, Stuart McLaren, David J McBride, Andrew Menzies, Laura J Mudie, Mark Maddison, Keiran M Raine, Serena Nik-Zainal, Sarah O'Meara, Jon W Teague, Ignacio Varela, David C Wedge, Ian Whitmore, Scott M Lippman, Ultan McDermott, Michael R Stratton, Peter J Campbell, Adel K El-Naggar, P Andrew Futreal (2013). Whole Exome Sequencing of Adenoid Cystic Carcinoma. The Journal of clinical investigation, 123(7) 2965–2968. Am Soc Clin Investig https://doi.org/10.1172/JCI67201.

Patrick S Tarpey, Sam Behjati, Susanna L Cooke, Peter Van Loo, David C Wedge, Nischalan Pillay, John Marshall, Sarah O'Meara, Helen Davies, Serena Nik-Zainal, David Beare, Adam P Butler, John Gamble, Claire Hardy, Jonathan Hinton, Mingming Jia, Alagu Jayakumar, David R Jones, Calli Latimer, Mark Maddison, Sancha Martin, Stuart McLaren, Andrew Menzies, Laura J Mudie, Keiran M Raine, Jon W Teague, Jose M C Tubio, Dina Halai, Roberto Tirabosco, M Fernanda Amary, Peter J Campbell, Michael R Stratton, Adrienne M Flanagan, P Andrew Futreal (2013). Frequent Mutation of the Major Cartilage Collagen Gene COL2A1 in Chondrosarcoma. Nature genetics, 45(8) 923–926. Nature Publishing Group https://doi.org/10.1038/ng.2668.

Serena Nik-Zainal, Ludmil Alexandrov, David C Wedge, Peter Van Loo, Keiran Raine, David Jones, Peter Campbell, Mike Stratton (2013). Kataegis and Other Somatic Mutational Signatures in Cancer. CHROMOSOME RESEARCH. , 21 S13–S13. SPRINGER VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS https://doi.org/https://doi-org.manchester.idm.oclc.org/10.1007/s10577-013-9364-x.

Elli Papaemmanuil, Yilong Li, Nicola E Potter, Ludmil B Alexandrov, Peter Van Loo, David C Wedge, Anthony Ford, Michael R Stratton, Mel Greaves, Peter J Campbell (2013). ETV6-RUNX1 ALL, INSIGHTS FROM INTEGRATIVE GENOMIC ANALYSIS. HAEMATOLOGICA. , 98(s1) 466–467. FERRATA STORTI FOUNDATION VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY.

Serena Nik-Zainal, Ben Taylor, Yee Ling Wu, David C Wedge, Cristina Rada, Mike Stratton, Michael Neuberger (2013). AID-APOBEC Cytidine Deaminases Can Mimic the Phenomenon of Localized Hypermutation in Cancer or Kataegis.. Cancer Research. , 73 611–611. AACR https://doi.org/10.1158/1538-7445.AM2013-611.

Anthoula A Argyri, Roger M Jarvis, David C Wedge, Yun Xu, Efstathios Z Panagou, Royston Goodacre, George-John E Nychas (2013). A Comparison of Raman and FT-IR Spectroscopy for the Prediction of Meat Spoilage. Food Control, 29(2) 461–470. Elsevier https://doi.org/10.1016/j.foodcont.2012.05.040.

Ludmil B Alexandrov, Serena Nik-Zainal, David C Wedge, Peter J Campbell, Michael R Stratton (2013). Deciphering Signatures of Mutational Processes Operative in Human Cancer. Cell Reports, 3(1) 246–259. Elsevier https://doi.org/10.1016/j.celrep.2012.12.008.

Andrew A Vaughan, Warwick B Dunn, J William Allwood, David C Wedge, Fiona H Blackhall, Anthony D Whetton, Caroline Dive, Royston Goodacre (2012). Liquid Chromatography–Mass Spectrometry Calibration Transfer and Metabolomics Data Fusion. Analytical chemistry, 84(22) 9848–9857. ACS Publications https://doi.org/10.1021/ac302227c.

Serena Nik-Zainal, Ludmil B Alexandrov, David C Wedge, Peter Van Loo, Keiran M Raine, David R Jones, P Andrew Futreal, Peter J Campbell, Mike Stratton (2012). 604 Cancer Genomics, Epigenetics and Genomic Instability. Mutational Processes Shaping the Genomes of Twenty-One Breast Cancers. European Journal of Cancer, 48 S144. https://doi.org/10.1016/S0959-8049(12)71258-3.

Serena Nik-Zainal, Peter Van Loo, David C Wedge, Ludmil B Alexandrov, Christopher D Greenman, King Wai Lau, Keiran Raine, David Jones, John Marshall, Manasa Ramakrishna, Adam Shlien, Susanna L Cooke, Jonathan Hinton, Andrew Menzies, Lucy A Stebbings, Catherine Leroy, Mingming Jia, Richard Rance, Laura J Mudie, Stephen J Gamble, Philip J Stephens, Stuart McLaren, Patrick S Tarpey, Elli Papaemmanuil, Helen R Davies, Ignacio Varela, David J McBride, Graham R Bignell, Kenric Leung, Adam P Butler, Jon W Teague, Sancha Martin, Goran Jonsson, Odette Mariani, Sandrine Boyault, Penelope Miron, Aquila Fatima, Anita Langerod, Samuel AJR Aparicio, Andrew M Tutt, Anieta M Sieuwerts, Ake Borg, Gilles Thomas, Anne Vincent-Salomon, Andrea L Richardson, Anne-Lise Borresen-Dale, P Andrew Futreal, Michael R Stratton, Peter J Campbell (2012). The Life History of 21 Breast Cancers. Cell, 149(5) 994–1007. Elsevier https://doi.org/10.1016/j.cell.2012.04.023.

Serena Nik-Zainal, Ludmil B Alexandrov, David C Wedge, Peter Van Loo, Christopher D Greenman, Keiran Raine, David Jones, Jonathan Hinton, John Marshall, Lucy A Stebbings, Andrew Menzies, Sancha Martin, Kenric Leung, Lina Chen, Catherine Leroy, Manasa Ramakrishna, Richard Rance, King Wai Lau, Laura J Mudie, Ignacio Varela, David J McBride, Graham R Bignell, Susanna L Cooke, Adam Shlien, John Gamble, Ian Whitmore, Mark Maddison, Patrick S Tarpey, Helen R Davies, Elli Papaemmanuil, Philip J Stephens, Stuart McLaren, Adam P Butler, Jon W Teague, Goran Jonsson, Judy E Garber, Daniel Silver, Penelope Miron, Aquila Fatima, Sandrine Boyault, Anita Langerod, Andrew M Tutt, John W M Martens, Samuel AJR Aparicio, Ake Borg, Anne Vincent-Salomon, Gilles Thomas, Anne-Lise Borresen-Dale, Andrea L Richardson, Michael S Neuberger, P Andrew Futreal, Peter J Campbell, Michael R Stratton (2012). Mutational Processes Molding the Genomes of 21 Breast Cancers. Cell, 149(5) 979–993. Elsevier https://doi.org/10.1016/j.cell.2012.04.024.

Philip J Stephens, Patrick S Tarpey, Helen Davies, Peter Van Loo, Chris Greenman, David C Wedge, Serena Nik-Zainal, Sancha Martin, Ignacio Varela, Graham R Bignell, Lucy R Yates, Elli Papaemmanuil, David Beare, Adam P Butler, Angela Cheverton, John Gamble, Jonathan Hinton, Mingming Jia, Alagu Jayakumar, David Jones, Calli Latimer, King Wai Lau, Stuart McLaren, David J McBride, Andrew Menzies, Laura J Mudie, Keiran M Raine, Roland Rad, Michael Spencer Chapman, Jon W Teague, Douglas F Easton, Anita Langerod, The Oslo Breast Cancer Consortium (OSBREAC), Ming Ta Michael Lee, Chen-Yang Shen, Benita Tan Kiat Tee, Bernice Wong Huimin, Annegien Broeks, Ana Cristina Vargas, Gulisa Turashvili, John W M Martens, Aquila Fatima, Penelope Miron, Suet-Feung Chin, Gilles Thomas, Sandrine Boyault, Odette Mariani, Sunil R Lakhani, Marc van de Vijver, Laura Van't Veer, John Foekens, Christine Desmedt, Christos Sotiriou, Andrew M Tutt, Carlos Caldas, Jorge S Reis-Filho, Samuel AJR Aparicio, Anne Vincent-Salomon, Anne-Lise Borresen-Dale, Andrea L Richardson, Peter J Campbell, P Andrew Futreal, Michael R Stratton (2012). The Landscape of Cancer Genes and Mutational Processes in Breast Cancer. Nature, 486(7403) 400–404. Nature Publishing Group https://doi.org/10.1038/nature11017.

Peter Van Loo, David C Wedge, Serena Nik-Zainal, Michael R Stratton, Andrew Futreal, Peter J Campbell, The International Cancer Genome Consortium Breast Cancer Working Group (2012). Exploring the Subclonal Architecture of Breast Cancer. Cancer Research, 72(8) 5055–5055. AACR https://doi.org/10.1158/1538-7445.AM2012-5055.

Elizabeth P Murchison, Ole B Schulz-Trieglaff, Zemin Ning, Ludmil B Alexandrov, Markus J Bauer, Beiyuan Fu, Matthew Hims, Zhihao Ding, Sergii Ivakhno, Caitlin Stewart, Bee Ling Ng, Wendy Wong, Bronwen Aken, Simon White, Amber Alsop, Jennifer Becq, Graham R Bignell, R Keira Cheetham, William Cheng, Thomas R Connor, Anthony J Cox, Zhi-Ping Feng, Yong Gu, Russell J Grocock, Simon R Harris, Irina Khrebtukova, Zoya Kingsbury, Mark Kowarsky, Alexandre Kreiss, Shujun Luo, John Marshall, David J McBride, Lisa Murray, Anne-Maree Pearse, Keiran M Raine, Isabelle Rasolonjatovo, Richard Shaw, Philip Tedder, Carolyn Tregidgo, Albert J Vilella, David C Wedge, Gregory M Woods, Niall Gormley, Sean Humphray, Gary Schroth, Geoffrey Smith, Kevin Hall, Stephen M J Searle, Nigel P Carter, Anthony T Papenfuss, P Andrew Futreal, Peter J Campbell, Fentang Yang, David R Bentley, Dirk J Evers, Michael R Stratton (2012). Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer. Cell, 148(4) 780–791. Elsevier https://doi.org/10.1016/j.cell.2011.11.065.

Claire E Eyers, Craig Lawless, David C Wedge, King Wai Lau, Simon J Gaskell, Simon J Hubbard (2011). CONSeQuence: Prediction of Reference Peptides for Absolute Quantitative Proteomics Using Consensus Machine Learning Approaches. Molecular & Cellular Proteomics, 10(11) ASBMB https://doi.org/10.1074/mcp.M110.003384.

David C Wedge, J William Allwood, Warwick Dunn, Andrew A Vaughan, Kathryn Simpson, Marie Brown, Lynsey Priest, Fiona H Blackhall, Anthony D Whetton, Caroline Dive, Royston Goodacre (2011). Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer. Analytical chemistry, 83(17) 6689–6697. ACS Publications https://doi.org/10.1021/ac2012224.

Marie Brown, David C Wedge, Royston Goodacre, Douglas B Kell, Philip N Baker, Louise C Kenny, Mamas A Mamas, Ludwig Neyses, Warwick B Dunn (2011). Automated Workflows for Accurate Mass-Based Putative Metabolite Identification in LC-MS-Derived Metabolomic Datasets. Bioinformatics, 27(8) 1108–1112. Oxford University Press https://doi.org/10.1093/bioinformatics/btr079.

David C Wedge, Ritesh Krishna, Paul Blackhurst, Jennifer A Siepen, Andrew R Jones, Simon J Hubbard (2011). FDRAnalysis: A Tool for the Integrated Analysis of Tandem Mass Spectrometry Identification Results from Multiple Search Engines. Journal of proteome research, 10(4) 2088–2094. ACS Publications https://doi.org/10.1021/pr101157s.

William Rowe, David C Wedge, Mark Platt, Douglas B Kell, Joshua Knowles (2010). Predictive Models for Population Performance on Real Biological Fitness Landscapes. Bioinformatics, 26(17) 2145–2152. Oxford University Press https://doi.org/10.1093/bioinformatics/btq353.

William Rowe, Mark Platt, David C Wedge, Philip JR Day, Douglas B Kell, elax JD Knowles (2010). Convergent Evolution to an Aptamer Observed in Small Populations on DNA Microarrays. Physical Biology, 7(3) 036007. IOP Publishing https://doi.org/doi.org/10.1088/1478-3975/7/3/036007.

William Rowe, Mark Platt, David C Wedge, Philip J Day, Douglas B Kell, Joshua Knowles (2010). Analysis of a Complete DNA–Protein Affinity Landscape. Journal of The Royal Society Interface, 7(44) 397–408. The Royal Society https://doi.org/10.1098/rsif.2009.0193.

J Kettle, S Whitelegg, elax AM Song, David C Wedge, L Kotacka, V Kolarik, elax MB Madec, elax SG Yeates, elax ML Turner (2010). Fabrication of Planar Organic Nanotransistors Using Low Temperature Thermal Nanoimprint Lithography for Chemical Sensor Applications. Nanotechnology, 21(7) 075301. IOP Publishing https://doi.org/doi.org/10.1088/0957-4484/21/7/075301.

David C Wedge, Arindam Das, Rene Dost, Jeff Kettle, Marie-Beatrice Madec, John J Morrison, Martin Grell, Douglas B Kell, Tim H Richardson, Stephen Yeates, Michael L Turner (2009). Real-Time Vapour Sensing Using an OFET-Based Electronic Nose and Genetic Programming. Sensors and Actuators B: Chemical, 143(1) 365–372. Elsevier https://doi.org/10.1016/j.snb.2009.09.030.

Alex P Harding, David C Wedge, Paul LA Popelier (2009). P K a Prediction from “Quantum Chemical Topology” Descriptors. Journal of chemical information and modeling, 49(8) 1914–1924. ACS Publications https://doi.org/10.1021/ci900172h.

Mark Platt, William Rowe, David C Wedge, Douglas B Kell, Joshua Knowles, Philip JR Day (2009). Aptamer Evolution for Array-Based Diagnostics. Analytical biochemistry, 390(2) 203–205. Elsevier https://doi.org/10.1016/j.ab.2009.04.013.

A Das, R Dost, elax TH Richardson, M Grell, elax DC Wedge, elax DB Kell, elax JJ Morrison, elax ML Turner (2009). Low Cost, Portable, Fast Multiparameter Data Acquisition System for Organic Transistor Odour Sensors. Sensors and Actuators B: Chemical, 137(2) 586–591. Elsevier https://doi.org/10.1016/j.snb.2009.01.006.

David C Wedge, William Rowe, Douglas B Kell, Joshua Knowles (2009). In Silico Modelling of Directed Evolution: Implications for Experimental Design and Stepwise Evolution. Journal of theoretical biology, 257(1) 131–141. Elsevier https://doi.org/10.1016/j.jtbi.2008.11.005.

Christopher G Knight, Mark Platt, William Rowe, David C Wedge, Farid Khan, Philip JR Day, Andy McShea, Joshua Knowles, Douglas B Kell (2009). Array-Based Evolution of DNA Aptamers Allows Modelling of an Explicit Sequence-Fitness Landscape. Nucleic acids research, 37(1) e6–e6. Oxford University Press https://doi.org/10.1093/nar/gkn899.

David C Wedge, Douglas B Kell (2008). Rapid Prediction of Optimum Population Size in Genetic Programming Using a Novel Genotype- Fitness Correlation. Proceedings of the 10th Annual Conference on Genetic and Evolutionary Computation. 1315–1322. https://doi.org/10.1145/1389095.1389346.

David C Wedge, Simon J Gaskell, Simon J Hubbard, Douglas B Kell, King Wai Lau, Claire Eyers (2007). Peptide Detectability Following ESI Mass Spectrometry: Prediction Using Genetic Programming. Proceedings of the 9th Annual Conference on Genetic and Evolutionary Computation. 2219–2225. https://doi.org/10.1145/1276958.1277382.

David C Wedge, David M Ingram, David A McLean, Clive G Mingham, Zuhair A Bandar (2006). On Global-Local Artificial Neural Networks for Function Approximation. IEEE TRANSACTIONS ON NEURAL NETWORKS, 17(4) 942–952. IEEE.

David C Wedge (2006). Wave Overtopping Prediction Using Global-Local Artificial Neural Networks.

David C Wedge, David M Ingram, Clive G Mingham, David A McLean, Zuhair A Bandar (2005). Neural Network Architectures and Overtopping Predictions. Proceedings of the Institution of Civil Engineers-Maritime Engineering. , 158 123–133. Thomas Telford Ltd https://doi.org/10.1680/maen.2005.158.3.123.

David C Wedge, David Ingram, David McLean, Clive Mingham, Zuhair Bandar (2005). A Global-Local Artificial Neural Network with Application to Wave Overtopping Prediction. International Conference on Artificial Neural Networks. 109–114. Springer https://doi.org/10.1007/11550907_18.

David J McBride, Dariush Etemadmoghadam, Susanna L Cooke, Kathryn Alsop, Joshy George, Adam Butler, Juok Cho, Danushka Galappaththige, Chris Greenman, Karen D Howarth, King Wai Lau, Charlotte K Ng, Keiran M Raine, Jon W Teague, David C Wedge, Australian Ovarian Cancer Study Group, Xavier Caubit, Michael R Stratton, James D Brenton, Peter J Campbell, P Andrew Futreal, David D L Bowtell (0001). Tandem Duplication of Chromosomal Segments Is Common in Ovarian and Breast Cancer Genomes. The Journal of pathology, 227(4) 446–455. Wiley Online Library https://doi.org/10.1002/path.4042.

Weerachai Jaratlerdsiri, Jue Jiang, Tingting Gong, Sean M Patrick, Cali Willet, Tracy Chew, Ruth J Lyons, Anne-Maree Haynes, Gabriela Pasqualim, Melanie Louw, James G Kench, Raymond Campbell, Lisa G Horvath, Eva K F Chan, David C Wedge, Rosemarie Sadsad, Ilma Simoni Brum, Shingai B A Mutambirwa, Phillip D Stricker, M S Riana Bornman, Vanessa M Hayes (0001). African-Specific Molecular Taxonomy of Prostate Cancer. Nature, 609 https://doi.org/10.1038/s41586-022-05154-6.