One in Two Podcast on Breast Cancer in Nigeria

The Manchester Cancer Research Centre today released an episode of their popular One in Two podcast, in which Sally Best spoke to David Wedge about his recent study of breast cancer in Nigeria. In the study, we found that a gene called GATA3 was more commonly mutated in breast cancers in Nigeria than in Black or White women in the USA. In Nigeria, the cancers were also more likely to be genomically unstable and to have higher levels of intratumoural heterogeneity. We identified a novel mutational signature, which may be an indicator of environmental exposure to mutagens or of genetic predisposition. All of these factors go some way towards explaining why Black women are likely to be diagnosed at a younger age and with more aggressive types of breast cancer than women of other ethnicities. It also suggests potential therapeutic interventions that may be more effective in Black communities in Nigeria and throughout the world.

To read our paper on breast cancer in Nigeria, go to the Nature Communications website.

To listen to the podcast, go to Spotify, Apple podcasts or YouTube.

Starting in 2024, the MCRC also now provide a video version of the One in Two podcast.