Pan-Cancer Analysis of Whole Genomes

Cancer is a complex disease and the analysis of large numbers of tumours is key to understanding the factors that determine their virulence. The International Cancer Genome Consortium (ICGC) has collected and Whole-Genome Sequenced several thousand cancer samples. David co-led the Pan-Cancer Analysis of Whole Genomes (PCAWG) Working Group on Evolution and Heterogeneity, an international collaboration that is using the DNA sequences of 2800 of these cancer samples to study evolution and heterogeneity across more than 30 different cancer types, including prostate, breast, lung, oesophageal and ovarian cancers.